PMID- 31426284
OWN - NLM
STAT- MEDLINE
DCOM- 20200116
LR  - 20221207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 16
DP  - 2019 Aug 16
TI  - Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and 
      Improves the Picryl Chloride-Induced Contact Dermatitis.
LID - 10.3390/molecules24162970 [doi]
LID - 2970
AB  - Allergic disease is one of the most important and common health problems 
      worldwide. We have previously demonstrated that a fig leaf-derived lactic acid 
      bacterium Lactobacillus (Lb.) paracasei IJH-SONE68 produces a novel 
      exopolysaccharide (EPS). Furthermore, we have shown that the EPS inhibits the 
      catalytic activity of hyaluronidase (EC 3.2.1.36) promoting inflammatory 
      reactions. To evaluate the anti-allergy and anti-inflammatory effects of the EPS, 
      in the present study, we employed the picryl-chloride-induced delayed-type (type 
      IV) allergy model mice, which is used to evaluate the contact dermatitis. Oral 
      administration of the EPS was observed to reduce the ear swelling in the model 
      mice. We also observed that the overexpression of ear interleukin-4 (T helper 
      (Th) 2 cytokine) mRNA and the increase in serum immunoglobulin E (IgE) are 
      repressed. However, the expression of interferon-gamma (Th1 cytokine) was not 
      accelerated in all of the allergen-challenged model mice. The improvement may be 
      responsible for the Th2 downregulation rather than the Th1 upregulation. In 
      addition, the symptom of immediate-type (type I) allergy model mice was improved 
      by oral administration of the IJH-SONE68 cell (data not shown). We can conclude 
      that the IJH-SONE68-derived EPS is useful to improve the type I and IV allergies 
      including atopic dermatitis.
FAU - Noda, Masafumi
AU  - Noda M
AD  - Department of Probiotic Science for Preventive Medicine, Graduate School of 
      Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, 
      Hiroshima 734-8551, Japan.
FAU - Sultana, Nasrin
AU  - Sultana N
AD  - Department of Probiotic Science for Preventive Medicine, Graduate School of 
      Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, 
      Hiroshima 734-8551, Japan.
FAU - Hayashi, Ikue
AU  - Hayashi I
AD  - Central Research Laboratory, Graduate School of Biomedical and Health Sciences, 
      Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Fukamachi, Mitsuhiro
AU  - Fukamachi M
AD  - Asahi Kohsan Co., Ltd., Shinjuku 1-1-14, Shinjuku-ku, Tokyo 160-0022, Japan.
FAU - Sugiyama, Masanori
AU  - Sugiyama M
AD  - Department of Probiotic Science for Preventive Medicine, Graduate School of 
      Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, 
      Hiroshima 734-8551, Japan. sugi@hiroshima-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20190816
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Allergens)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Dermatologic Agents)
RN  - 0 (Il4 protein, mouse)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.2.1.35 (Hyaluronoglucosaminidase)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
SB  - IM
MH  - Administration, Oral
MH  - Allergens/immunology/metabolism
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - Anti-Inflammatory Agents/isolation & purification/*pharmacology
MH  - Dermatitis, Contact/etiology/immunology/pathology/*prevention & control
MH  - Dermatologic Agents/isolation & purification/*pharmacology
MH  - Disease Models, Animal
MH  - Ear
MH  - Gene Expression/drug effects
MH  - Hyaluronoglucosaminidase/antagonists & inhibitors/immunology/metabolism
MH  - Immunoglobulin E/blood/genetics
MH  - Interferon-gamma/genetics/immunology
MH  - Interleukin-4/genetics/immunology
MH  - Lacticaseibacillus paracasei/*chemistry/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Picryl Chloride/administration & dosage
MH  - Polysaccharides, Bacterial/isolation & purification/*pharmacology
MH  - Th1 Cells/drug effects/immunology
MH  - Th2 Cells/drug effects/immunology
PMC - PMC6720527
OTO - NOTNLM
OT  - Lactobacillus paracasei
OT  - contact dermatitis
OT  - exopolysaccharide
OT  - lactic acid bacteria
COIS- The authors declare no conflicts of interest.
EDAT- 2019/08/21 06:00
MHDA- 2020/01/17 06:00
PMCR- 2019/08/16
CRDT- 2019/08/21 06:00
PHST- 2019/07/21 00:00 [received]
PHST- 2019/08/14 00:00 [revised]
PHST- 2019/08/14 00:00 [accepted]
PHST- 2019/08/21 06:00 [entrez]
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2020/01/17 06:00 [medline]
PHST- 2019/08/16 00:00 [pmc-release]
AID - molecules24162970 [pii]
AID - molecules-24-02970 [pii]
AID - 10.3390/molecules24162970 [doi]
PST - epublish
SO  - Molecules. 2019 Aug 16;24(16):2970. doi: 10.3390/molecules24162970.