PMID- 31427478
OWN - NLM
STAT- MEDLINE
DCOM- 20200918
LR  - 20200918
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 9
DP  - 2019 Sep 30
TI  - Circular RNA MYLK serves as an oncogene to promote cancer progression via 
      microRNA-195/cyclin D1 axis in laryngeal squamous cell carcinoma.
LID - BSR20190227 [pii]
LID - 10.1042/BSR20190227 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common aggressive head and neck 
      cancer. Circular RNAs (circRNAs) are implicated in numerous physiological and 
      pathological processes, including tumorigenesis. The present study aimed to 
      investigate the expression profile and biological role of circMYLK in LSCC. We 
      found that circMYLK was highly expressed in LSCC tissues and cell lines. circMYLK 
      overexpression promoted LSCC cell proliferation and G(1)/S cell cycle transition; 
      whereas circMYLK knockdown had the contrary effects. Mechanistically, circMYLK 
      can serve as a competing endogenous RNA for miR-195 to increase cyclin D1 
      expression in LSCC, and rescue experiments further showed that restoration of 
      miR-195 could block the oncogenic role of circMYLK in LSCC. In conclusion, our 
      findings indicate that the circMYLK/miR-195/cyclin D1 regulatory axis could 
      affect the proliferation and cell cycle progression of LSCC cells, and may 
      provide a novel therapeutic target for the treatment of LSCC.
CI  - (c) 2019 The Author(s).
FAU - Duan, Xiaohui
AU  - Duan X
AD  - Department of Otorhinolaryngology Head and Neck, Affiliated Hospital of Hebei 
      Engineering University, Handan 056002, Hebei Province, China.
FAU - Shen, Na
AU  - Shen N
AD  - Department of Otorhinolaryngology Head and Neck, The 4th Central Hospital of 
      Tianjin, Tianjin 300140, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Anesthesia, Affiliated Hospital of Hebei Engineering University, 
      Handan 056002, Hebei Province, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Neurology, Affiliated Hospital of Hebei Engineering University, 
      Handan 056002, Hebei Province, China.
FAU - Zhu, Qinghua
AU  - Zhu Q
AD  - Department of Neurosurgery, Affiliated Hospital of Hebei Engineering University, 
      Handan 056002, Hebei Province, China.
FAU - Zhai, Zhihai
AU  - Zhai Z
AUID- ORCID: 0000-0002-0749-7086
AD  - Department of Aesthetic Plastic Surgery, Affiliated Hospital of Hebei Engineering 
      University, Handan 056002, Hebei Province, China dr_zhaizhihai66@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190903
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (CCND1 protein, human)
RN  - 0 (Carcinogens)
RN  - 0 (MIRN195 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
RN  - 0 (RNA, Small Interfering)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - Base Pairing
MH  - Base Sequence
MH  - Carcinogens
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics/pathology/surgery
MH  - Cell Cycle/genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Cyclin D1/*genetics/metabolism
MH  - Disease Progression
MH  - Epithelial Cells/metabolism/pathology
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*genetics/pathology/surgery
MH  - Male
MH  - MicroRNAs/*genetics/metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - RNA, Circular/antagonists & inhibitors/*genetics/metabolism
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Signal Transduction
PMC - PMC6722494
OTO - NOTNLM
OT  - cell cycle
OT  - circular RNA MYLK
OT  - cyclin D1
OT  - laryngeal squamous cell carcinoma
OT  - microRNA-195
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/08/21 06:00
MHDA- 2020/09/20 06:00
PMCR- 2019/09/03
CRDT- 2019/08/21 06:00
PHST- 2019/01/26 00:00 [received]
PHST- 2019/07/03 00:00 [revised]
PHST- 2019/08/01 00:00 [accepted]
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2020/09/20 06:00 [medline]
PHST- 2019/08/21 06:00 [entrez]
PHST- 2019/09/03 00:00 [pmc-release]
AID - BSR20190227 [pii]
AID - 10.1042/BSR20190227 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Sep 3;39(9):BSR20190227. doi: 10.1042/BSR20190227. Print 2019 
      Sep 30.