PMID- 31429093
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1099-1263 (Electronic)
IS  - 0260-437X (Linking)
VI  - 40
IP  - 2
DP  - 2020 Feb
TI  - Reproductive disorders in female rats after prenatal exposure to sodium arsenite.
PG  - 214-223
LID - 10.1002/jat.3897 [doi]
AB  - Arsenic is a metalloid widely found in the environment in organic and inorganic 
      forms. Exposure to inorganic arsenic forms via drinking water has been associated 
      with an increased incidence of negative health effects, including reproductive 
      disorders and dysfunction of the endocrine system. However, the impact of arsenic 
      exposure on female reproductive development is still unclear. Therefore, in the 
      present study, we evaluated the effects of prenatal exposure to arsenic on the 
      initial sexual development and puberty onset, and in the morphology of the female 
      reproductive organs, estrous cycle regularity and fertility parameters during 
      adulthood. To do that, pregnant female Wistar rats were exposed to 10 mg/L sodium 
      arsenite via drinking water from gestational day (GD) 1 until GD 21 and the 
      female offspring was evaluated in different postnatal days. Our results showed 
      that prenatal arsenic exposure induced a decrease of litter weight and 
      morphological masculinization in females at postnatal day 1. Moreover, these 
      females had a delay in the age of puberty onset and alteration in estrous cycle 
      number and length. During adulthood, females from the sodium arsenite group 
      showed an increase in endometrium, myometrium and perimetrium areas, and an 
      imbalance in uterine antioxidant enzyme activity. These animals also presented an 
      increase in post-implantation loss and reabsorption number, leading to reduced 
      viable fetus number. In conclusion, prenatal arsenic exposure in rats was able to 
      promote female masculinization, alter sexual development and impair reproductive 
      performance.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Souza, Ana Claudia Ferreira
AU  - Souza ACF
AUID- ORCID: 0000-0001-5840-2641
AD  - Department of Animal Biology, Universidade Federal Rural do Rio de Janeiro, Rio 
      de Janeiro, Brazil.
AD  - Department of Animal Science, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
FAU - Ervilha, Luiz Otavio Guimaraes
AU  - Ervilha LOG
AD  - Department of General Biology, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
FAU - Coimbra, John Lennon Paiva
AU  - Coimbra JLP
AD  - Department of General Biology, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
FAU - Bastos, Daniel Silva Sena
AU  - Bastos DSS
AD  - Department of General Biology, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
FAU - Guimaraes, Simone Eliza Facioni
AU  - Guimaraes SEF
AD  - Department of Animal Science, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
FAU - Machado-Neves, Mariana
AU  - Machado-Neves M
AD  - Department of General Biology, Universidade Federal de Vicosa, Vicosa, Minas 
      Gerais, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190819
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Arsenites)
RN  - 0 (Sodium Compounds)
SB  - IM
MH  - Animals
MH  - Arsenites/*toxicity
MH  - Body Weight/drug effects
MH  - Estrous Cycle/*drug effects
MH  - Female
MH  - Fertility/drug effects
MH  - Maternal Exposure/*adverse effects
MH  - Models, Animal
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Puberty/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reproduction/*drug effects
MH  - Sodium Compounds/*toxicity
OTO - NOTNLM
OT  - arsenic
OT  - female reproduction
OT  - maternal exposure
OT  - oxidative stress
OT  - reproductive toxicology
OT  - sexual development
EDAT- 2019/08/21 06:00
MHDA- 2021/07/06 06:00
CRDT- 2019/08/21 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/06/27 00:00 [revised]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2019/08/21 06:00 [entrez]
AID - 10.1002/jat.3897 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2020 Feb;40(2):214-223. doi: 10.1002/jat.3897. Epub 2019 Aug 19.