PMID- 31429741
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200225
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Aug 20
TI  - A pragmatic application of endobronchial ultrasound-guided transbronchial needle 
      aspiration: a single institution experience.
PG  - 155
LID - 10.1186/s12890-019-0909-4 [doi]
LID - 155
AB  - BACKGROUND: Endobronchial ultrasound-guided trans-bronchial needle aspiration 
      (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of 
      benign and malignant pulmonary and non-pulmonary disease. Previous studies have 
      established the utility of EBUS-TBNA in narrowly defined indications and 
      populations. In this pragmatic 'real world' study we have analysed the use of 
      EBUS-TBNA for a variety of clinical presentations and its clinical application in 
      conjunction with other invasive investigations. METHODS: All EBUS-TBNA procedures 
      performed at Sir Charles Gardiner Hospital in 2012-2014 were reviewed 
      retrospectively, using relevant hospital databases. RESULTS: A total of 327 
      patients underwent 337 EBUS-TBNA procedures. EBUS-TBNA procedures were used to 
      diagnose a wide spectrum of benign and malignant conditions. The main application 
      was in the diagnosis and staging of malignant conditions (70.6%), and in the 
      diagnosis of benign conditions such as sarcoidosis 40 (12.2%), and 
      silicoanthracosis 17 (5.2%). EBUS-TBNA was sufficient to diagnose and stage the 
      disease as a single stand-alone invasive procedure in 191 (59.2%) patients. 
      EBUS-TBNA was the final invasive procedure undertaken in 283 (87.6%) patients. 
      Only 13.3% of non small cell lung cancer (NSCLC) patients who had EBUS-TBNA as a 
      first investigation required multiple procedures compared to 51.1% of all NSCLC 
      patients undergoing EBUS-TBNA. Overall sensitivity, specificity, NPV and 
      diagnostic accuracy for EBUS-TBNA were 89.7, 100, 85.1 and 89.9%, respectively 
      and three minor complications (0.9%) occurred as a result of the procedure. 
      CONCLUSIONS: EBUS-TBNA was undertaken for a wide variety of clinical conditions. 
      Good diagnostic accuracy and safety profiles were demonstrated for the procedure, 
      supporting its application as a first line investigation in the diagnosis and/or 
      staging of a range of malignant and benign conditions. Our study was unique in 
      its documentation of the use of EBUS-TBNA in a real-world setting in conjunction 
      with other invasive modalities. EBUS-TBNA was utilised as a stand alone invasive 
      procedure in more than half of the patients. Importantly, in NSCLC, when 
      EBUS-TBNA was performed as primary diagnostic and staging investigation, less 
      patients underwent subsequent invasive procedures.
FAU - Bailey, Nicola
AU  - Bailey N
AD  - Cancer and Palliative Care Research and Evaluation Unit (CaPCREU), School of 
      Medicine, The University of Western Australia, M581, 35 Stirling Hwy, Crawley, 
      6009, Australia.
FAU - Krisnadi, Zoe
AU  - Krisnadi Z
AD  - Cancer and Palliative Care Research and Evaluation Unit (CaPCREU), School of 
      Medicine, The University of Western Australia, M581, 35 Stirling Hwy, Crawley, 
      6009, Australia.
FAU - Kaur, Raena
AU  - Kaur R
AD  - Cancer and Palliative Care Research and Evaluation Unit (CaPCREU), School of 
      Medicine, The University of Western Australia, M581, 35 Stirling Hwy, Crawley, 
      6009, Australia.
FAU - Mulrennan, Siobhain
AU  - Mulrennan S
AD  - Department of Respiratory Medicine, Sir Charles Gairdner Hospital, 1 Hospital 
      Avenue, Nedlands, 6009, Australia.
AD  - School of Medicine and Pharmacology, The University of Western Australia, M507, 
      35 Stirling Hwy, Crawley, 6009, Australia.
FAU - Phillips, Martin
AU  - Phillips M
AD  - Department of Respiratory Medicine, Sir Charles Gairdner Hospital, 1 Hospital 
      Avenue, Nedlands, 6009, Australia.
FAU - Slavova-Azmanova, Neli
AU  - Slavova-Azmanova N
AUID- ORCID: 0000-0003-0800-2943
AD  - Cancer and Palliative Care Research and Evaluation Unit (CaPCREU), School of 
      Medicine, The University of Western Australia, M581, 35 Stirling Hwy, Crawley, 
      6009, Australia. neli.slavova-azmanova@uwa.edu.au.
LA  - eng
GR  - Vacation Scholarship 2015/2016/Cancer Council Western Australia/
GR  - N/A/Department of Health, Government of Western Australia/
PT  - Journal Article
DEP - 20190820
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Aged
MH  - Australia
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/*pathology
MH  - Databases, Factual
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Lung Diseases/diagnosis/*pathology
MH  - Lung Neoplasms/diagnosis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sarcoidosis/diagnosis/*pathology
MH  - Sensitivity and Specificity
MH  - Silicosis/diagnosis/pathology
PMC - PMC6701134
OTO - NOTNLM
OT  - Diagnosis
OT  - Endobronchial ultrasound
OT  - Lung cancer
OT  - Staging
OT  - Transbronchial needle aspiration
COIS- The authors declare that they have no competing interests.
EDAT- 2019/08/21 06:00
MHDA- 2020/02/12 06:00
PMCR- 2019/08/20
CRDT- 2019/08/21 06:00
PHST- 2018/02/03 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/21 06:00 [entrez]
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
PHST- 2019/08/20 00:00 [pmc-release]
AID - 10.1186/s12890-019-0909-4 [pii]
AID - 909 [pii]
AID - 10.1186/s12890-019-0909-4 [doi]
PST - epublish
SO  - BMC Pulm Med. 2019 Aug 20;19(1):155. doi: 10.1186/s12890-019-0909-4.