PMID- 31430134
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 20
IP  - 10
DP  - 2019 Oct 14
TI  - Bioinspired RGD-Engineered Bacteriophage Nanofiber Cues against Oxidative Stress.
PG  - 3658-3671
LID - 10.1021/acs.biomac.9b00640 [doi]
AB  - Instructive tissue engineering biomaterials provide a vascular niche and protect 
      oxidative stress in injured tissue. In this study, we exploited bioinspired 
      bacteriophage nanofibers, previously recognized by their biochemical and 
      structural cues inducing angiogenesis, as an antioxidant tissue engineering 
      material. We demonstrated that topological cues of Arg-Gly-Asp (RGD)-engineered 
      bacteriophage nanofibers provide angiogenic niches and cytoprotective functions 
      against cellular oxidative stress with increased expression of antioxidant 
      enzymes heme oxygenase-1 (HO-1) and NAD(P)H-quinone oxidoreductase 1 (NQO1) via 
      the extracellular-signal-regulated kinase (ERK)-nuclear factor erythroid 
      2-related factor2 (Nrf2)-mediated signaling pathway, where a high density of RGD 
      cues on the phage body support efficient interaction of cells with phage cues. 
      These bioinspired RGD-engineered bacteriophage nanofibers can serve as a novel 
      therapeutic platform for curing ischemic diseases.
FAU - Chae, Seon Yeong
AU  - Chae SY
AD  - BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , 
      Republic of Korea.
AD  - Department of Nano Fusion Technology , Pusan National University , Busan 46241 , 
      Republic of Korea.
FAU - Shrestha, Kshitiz Raj
AU  - Shrestha KR
AD  - BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , 
      Republic of Korea.
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital , Yangsan 50612 , Republic of Korea.
FAU - Jeong, Su-Nam
AU  - Jeong SN
AD  - BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , 
      Republic of Korea.
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital , Yangsan 50612 , Republic of Korea.
FAU - Park, Geuntae
AU  - Park G
AD  - BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , 
      Republic of Korea.
AD  - Department of Nano Fusion Technology , Pusan National University , Busan 46241 , 
      Republic of Korea.
FAU - Yoo, So Young
AU  - Yoo SY
AUID- ORCID: 0000-0001-8875-9289
AD  - BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , 
      Republic of Korea.
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital , Yangsan 50612 , Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190830
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 0 (Oligopeptides)
RN  - 0 (Stimuli Responsive Polymers)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (NQO1 protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Bacteriophage M13/*chemistry
MH  - HeLa Cells
MH  - Heme Oxygenase (Decyclizing)/metabolism
MH  - Human Umbilical Vein Endothelial Cells/metabolism/physiology
MH  - Humans
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - NAD(P)H Dehydrogenase (Quinone)/metabolism
MH  - NF-E2-Related Factor 2/metabolism
MH  - Nanofibers/*chemistry
MH  - Neovascularization, Physiologic
MH  - Oligopeptides/*chemistry
MH  - *Oxidative Stress
MH  - Stimuli Responsive Polymers/*chemistry
EDAT- 2019/08/21 06:00
MHDA- 2020/09/18 06:00
CRDT- 2019/08/21 06:00
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/08/21 06:00 [entrez]
AID - 10.1021/acs.biomac.9b00640 [doi]
PST - ppublish
SO  - Biomacromolecules. 2019 Oct 14;20(10):3658-3671. doi: 10.1021/acs.biomac.9b00640. 
      Epub 2019 Aug 30.