PMID- 31430505 OWN - NLM STAT- MEDLINE DCOM- 20200226 LR - 20200226 IS - 1096-0295 (Electronic) IS - 0273-2300 (Linking) VI - 108 DP - 2019 Nov TI - Dissipation rates and residue levels of diflubenzuron and difenoconazole on peaches and dietary risk assessment. PG - 104447 LID - S0273-2300(19)30211-9 [pii] LID - 10.1016/j.yrtph.2019.104447 [doi] AB - The dissipation kinetics, residue levels, and potential risks of diflubenzuron and difenoconazole on peaches were investigated under open field conditions. Two years of field trials were carried out in Shanghai, China, and the half-lives of diflubenzuron and difenoconazole on peaches ranged from 4.4 to 25d. Their terminal residue concentrations on peaches were 0.022-5.7 mg/kg after three of the tested sampling intervals. Based on the maximum residue levels (MRLs) of difenoconazole on peaches, a preharvest interval (PHI) of 14 d was proposed. A PHI of 10 d was proposed for diflubenzuron after a dietary safety assessment. During the safety assessment, the hazard quotient (HQ) and risk quotient (RQ) on peaches were determined. The results showed that the HQs (3.6-8.3%) and RQs(51-55%) of diflubenzuron were acceptable, proving that diflubenzuron poses no potential health risks. For difenoconazole, the HQs (0.027-0.071%) were satisfactory, but the RQs (115-116%) exceeded 100%, which indicated potential risk. CI - Copyright (c) 2019. Published by Elsevier Inc. FAU - Dong, Maofeng AU - Dong M AD - Pesticide Safety Evaluation Research Center, Institute for Agro-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, PR China. FAU - Ma, Lin AU - Ma L AD - Shanghai Agriculture Technical Extension Service Center, Shanghai, 201103, PR China. FAU - Zhan, Xiuping AU - Zhan X AD - Shanghai Agriculture Technical Extension Service Center, Shanghai, 201103, PR China. FAU - Chen, Jianbo AU - Chen J AD - Shanghai Agriculture Technical Extension Service Center, Shanghai, 201103, PR China. FAU - Huang, Lanqi AU - Huang L AD - Shanghai Agriculture Technical Extension Service Center, Shanghai, 201103, PR China. FAU - Wang, Weimin AU - Wang W AD - Pesticide Safety Evaluation Research Center, Institute for Agro-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, PR China. FAU - Zhao, Li AU - Zhao L AD - Shanghai Agriculture Technical Extension Service Center, Shanghai, 201103, PR China. Electronic address: zhaoli5741@aliyun.com. LA - eng PT - Journal Article DEP - 20190817 PL - Netherlands TA - Regul Toxicol Pharmacol JT - Regulatory toxicology and pharmacology : RTP JID - 8214983 RN - 0 (Dioxolanes) RN - 0 (Fungicides, Industrial) RN - 0 (Pesticide Residues) RN - 0 (Triazoles) RN - D9612XCH4P (difenoconazole) RN - J76U6ZSI8D (Diflubenzuron) SB - IM MH - Dietary Exposure/analysis MH - Diflubenzuron/*analysis MH - Dioxolanes/*analysis MH - Environmental Monitoring MH - Food Contamination/analysis MH - Fruit/*chemistry MH - Fungicides, Industrial/*analysis MH - Humans MH - Pesticide Residues/*analysis MH - *Prunus persica MH - Risk Assessment MH - Triazoles/*analysis OTO - NOTNLM OT - Dietary risk assessment OT - Difenoconazole OT - Diflubenzuron OT - Peach EDAT- 2019/08/21 06:00 MHDA- 2020/02/27 06:00 CRDT- 2019/08/21 06:00 PHST- 2019/04/20 00:00 [received] PHST- 2019/08/06 00:00 [revised] PHST- 2019/08/15 00:00 [accepted] PHST- 2019/08/21 06:00 [pubmed] PHST- 2020/02/27 06:00 [medline] PHST- 2019/08/21 06:00 [entrez] AID - S0273-2300(19)30211-9 [pii] AID - 10.1016/j.yrtph.2019.104447 [doi] PST - ppublish SO - Regul Toxicol Pharmacol. 2019 Nov;108:104447. doi: 10.1016/j.yrtph.2019.104447. Epub 2019 Aug 17.