PMID- 31430591
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2213-2201 (Electronic)
VI  - 8
IP  - 1
DP  - 2020 Jan
TI  - Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to 
      Staphylococcus aureus Antigens, and Underlying Systemic Inflammation.
PG  - 236-247.e3
LID - S2213-2198(19)30719-6 [pii]
LID - 10.1016/j.jaip.2019.08.013 [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory disease with 
      significant local and systemic inflammation and barrier disruption. AD is 
      associated with increased risk of allergen sensitization and skin colonization by 
      Staphylococcus aureus. The heterogeneity of AD is unknown, and its complexity 
      suggests its subdivision into several endotypes. OBJECTIVE: To evaluate 
      allergy-driven endotypic differences in patients with AD and identify proteomic 
      signatures to distinguish between inflammatory responses. To perform proteomic 
      profiling of allergen sensitivity, antibody levels to S aureus antigens, and 
      circulating inflammatory mediators to characterize AD subsets in 76 subjects with 
      moderate to severe AD and 39 healthy controls (HCs). METHODS: Sera were collected 
      from 76 subjects with moderate to severe AD and 39 HCs with no history of skin 
      disease. Serum was tested for levels of total serum immunoglobulin E (IgE) and 
      allergen-specific IgE using a panel of 119 allergens as well as IgE antibodies 
      against S aureus antigens, and was profiled for more than 1100 proteins by 
      SOMAscan to detect differential expression of inflammatory mediators. RESULTS: 
      Total serum IgE levels were significantly (P < .001) elevated in subjects with AD 
      versus controls. A greater percentage of subjects with AD were allergic compared 
      with HCs, and patients with AD tested positive to a greater number of allergens 
      than did HCs. IgE was upregulated across 4 allergen subsets (food, perennial, 
      seasonal, and mixed), and each allergen subset was associated with a distinct 
      inflammatory signature marked by a specific suite of upregulated proteins. 
      Finally, IgE antibodies against S aureus toxic shock syndrome toxin-1 were 
      significantly upregulated in subjects with seasonal allergy (P = .0430) and 
      perennial allergy (P = .00032). CONCLUSIONS: Overall, this study addresses the 
      heterogeneity of AD by characterizing subsets of AD on the basis of allergen 
      sensitization. It also demonstrates the differential systemic inflammation and S 
      aureus-specific antibody responses associated with the allergenic endotypes. 
      These unique proteomic signatures may be valuable for precise disease 
      characterization and subsequent personalized treatment.
CI  - Copyright (c) 2019 American Academy of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Leonard, Alexandra
AU  - Leonard A
AD  - Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.
FAU - Wang, Jingya
AU  - Wang J
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - Yu, Li
AU  - Yu L
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - Liu, Hao
AU  - Liu H
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - Estrada, Yeriel
AU  - Estrada Y
AD  - Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.
FAU - Greenlees, Lydia
AU  - Greenlees L
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - McPhee, Roderick
AU  - McPhee R
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - Ruzin, Alexey
AU  - Ruzin A
AD  - MedImmune, LLC, Gaithersburg, Md.
FAU - Guttman-Yassky, Emma
AU  - Guttman-Yassky E
AD  - Icahn School of Medicine at Mount Sinai Medical Center, New York, NY.
FAU - Howell, Michael D
AU  - Howell MD
AD  - MedImmune, LLC, Gaithersburg, Md. Electronic address: wvuscienstist@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190817
PL  - United States
TA  - J Allergy Clin Immunol Pract
JT  - The journal of allergy and clinical immunology. In practice
JID - 101597220
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens
MH  - *Dermatitis, Atopic/diagnosis
MH  - Humans
MH  - Inflammation
MH  - Proteomics
MH  - *Staphylococcus aureus
OTO - NOTNLM
OT  - Allergy
OT  - Atopic dermatitis
OT  - Inflammation
OT  - Proteomics
EDAT- 2019/08/21 06:00
MHDA- 2021/05/15 06:00
CRDT- 2019/08/21 06:00
PHST- 2019/01/10 00:00 [received]
PHST- 2019/08/06 00:00 [revised]
PHST- 2019/08/07 00:00 [accepted]
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2019/08/21 06:00 [entrez]
AID - S2213-2198(19)30719-6 [pii]
AID - 10.1016/j.jaip.2019.08.013 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol Pract. 2020 Jan;8(1):236-247.e3. doi: 
      10.1016/j.jaip.2019.08.013. Epub 2019 Aug 17.