PMID- 31430822
OWN - NLM
STAT- MEDLINE
DCOM- 20200807
LR  - 20200807
IS  - 1098-8785 (Electronic)
IS  - 0735-1631 (Linking)
VI  - 37
IP  - 1
DP  - 2020 Jan
TI  - Basal Insulin Analogs versus Neutral Protamine Hagedorn for Type 2 Diabetics.
PG  - 30-36
LID - 10.1055/s-0039-1694733 [doi]
AB  - OBJECTIVE: To determine whether basal insulin analogs reduce the rate of 
      composite neonatal morbidity compared with neutral protamine Hagedorn (NPH) in 
      women with type 2 diabetes mellitus (T2DM). STUDY DESIGN: This was a 
      retrospective cohort study of women with T2DM and singleton pregnancy at a single 
      tertiary center. Primary outcome was a composite neonatal morbidity of any of the 
      following: shoulder dystocia, large for gestational age, neonatal intensive care 
      unit admission, neonatal hypoglycemia, or respiratory distress syndrome. 
      Secondary outcomes were rates of maternal hypoglycemic events, hypertensive 
      disorders, preterm birth, and primary cesarean delivery. Adjusted relative risk 
      (aRR) and 95% confidence intervals (CI) were calculated. RESULTS: Of 233 women 
      with T2DM that met the inclusion criteria, 114 (49%) were treated with basal 
      insulin analogs and 119 (51%) with NPH. The rate of composite neonatal morbidity 
      was similar between groups (73 vs. 60%; aRR: 1.18; 95% CI: 0.92-1.51). There were 
      no differences in the rates of maternal adverse outcomes between the groups. 
      Basal insulin analog was associated with a lower rate of primary cesarean 
      delivery as compared with NPH (21 vs. 36%; aRR: 0.44; 95% CI: 0.25-0.78). 
      CONCLUSION: Among pregnant women with T2DM managed with either basal or NPH 
      insulin regimen, the rates of composite neonatal morbidity and maternal 
      complications were similar.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Fishel Bartal, Michal
AU  - Fishel Bartal M
AUID- ORCID: 0000-0003-4715-566X
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Ward, Clara
AU  - Ward C
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Refuerzo, Jerrie S
AU  - Refuerzo JS
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Ashimi, Sunbola S
AU  - Ashimi SS
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Joycelyn, Cornthwaite A
AU  - Joycelyn CA
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Chen, Han-Yang
AU  - Chen HY
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Chauhan, Suneet P
AU  - Chauhan SP
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Sibai, Baha M
AU  - Sibai BM
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and 
      Reproductive Sciences, McGovern Medical School, University of Texas Health 
      Science Center at Houston, Houston, Texas.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190820
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
RN  - 0 (Hypoglycemic Agents)
RN  - 2ZM8CX04RZ (Insulin Glargine)
RN  - 4FT78T86XV (Insulin Detemir)
RN  - 53027-39-7 (Insulin, Isophane)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemia/chemically induced
MH  - Hypoglycemic Agents/adverse effects/*therapeutic use
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*epidemiology
MH  - Insulin Detemir/adverse effects/*therapeutic use
MH  - Insulin Glargine/adverse effects/*therapeutic use
MH  - Insulin, Isophane/adverse effects/*therapeutic use
MH  - Logistic Models
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy in Diabetics/*drug therapy
MH  - Premature Birth/epidemiology
MH  - Retrospective Studies
MH  - Young Adult
COIS- None declared.
EDAT- 2019/08/21 06:00
MHDA- 2020/08/08 06:00
CRDT- 2019/08/21 06:00
PHST- 2019/08/21 06:00 [pubmed]
PHST- 2020/08/08 06:00 [medline]
PHST- 2019/08/21 06:00 [entrez]
AID - 10.1055/s-0039-1694733 [doi]
PST - ppublish
SO  - Am J Perinatol. 2020 Jan;37(1):30-36. doi: 10.1055/s-0039-1694733. Epub 2019 Aug 
      20.