PMID- 31431645
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Aug 20
TI  - Sex difference in IgE sensitization associated with alcohol consumption in the 
      general population.
PG  - 12131
LID - 10.1038/s41598-019-48305-y [doi]
LID - 12131
AB  - The association of alcohol consumption and immunoglobulin E (IgE) sensitization 
      is debated. Few population-based studies have investigated whether such 
      associations differ by sex. We explored the association of alcohol consumption 
      with IgE sensitization in the general population, stratified by sex. We analyzed 
      data for 1,723 adults from the 2010 Korean National Health and Nutrition 
      Examination Survey. We divided subjects into three groups according to their 
      self-reported alcohol consumption or serum level of gamma-glutamyltransferase 
      (GGT), an objective marker of alcohol consumption. After adjustments, the odds 
      ratios (ORs) of male high-risk drinkers were 2.09 (95% confidence interval [CI], 
      1.34-3.28) for total IgE and 1.71 (95% CI, 1.03-2.83) for Dermatophagoides 
      farinae (DF)-specific IgE compared with male low-risk drinkers. In females, the 
      dog-specific IgE level was associated with high-risk drinking (OR, 11.74; 95% CI, 
      2.04-67.24). The ORs of males in the high-serum-GGT group were 2.73 (95% CI, 
      1.72-4.33) for total IgE and 2.17 (95% CI, 1.35-3.47) for DF-specific IgE 
      compared with those in the low-serum-GGT group. This study suggests a possible 
      link between alcohol consumption and IgE sensitization, moreover, the risk of IgE 
      sensitization was significantly higher in male high-risk drinkers. Therefore, 
      clinicians should consider the risk of IgE sensitization possibly afflicting male 
      high-risk drinkers.
FAU - Roh, Daeyoung
AU  - Roh D
AUID- ORCID: 0000-0001-7242-9496
AD  - Mind-neuromodulation Laboratory and Department of Psychiatry, Chuncheon Sacred 
      Heart Hospital, Hallym University College of Medicine, Chuncheon-si, Gangwon-do, 
      Republic of Korea.
FAU - Lee, Dong-Hee
AU  - Lee DH
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Lee, Sang-Kyu
AU  - Lee SK
AD  - Mind-neuromodulation Laboratory and Department of Psychiatry, Chuncheon Sacred 
      Heart Hospital, Hallym University College of Medicine, Chuncheon-si, Gangwon-do, 
      Republic of Korea.
FAU - Kim, Soo Whan
AU  - Kim SW
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Kim, Sung Won
AU  - Kim SW
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Cho, Jin Hee
AU  - Cho JH
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Kim, Byung-Guk
AU  - Kim BG
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Shin, Ji-Hyeon
AU  - Shin JH
AUID- ORCID: 0000-0003-0934-8700
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea. tachyon0217@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190820
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/blood/*epidemiology/*immunology
MH  - Alcohol-Related Disorders/blood/epidemiology/immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/*epidemiology/*immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Self Report
MH  - Sex Factors
MH  - Socioeconomic Factors
MH  - Young Adult
MH  - gamma-Glutamyltransferase/blood
PMC - PMC6702201
COIS- The authors declare no competing interests.
EDAT- 2019/08/23 06:00
MHDA- 2020/10/24 06:00
PMCR- 2019/08/20
CRDT- 2019/08/22 06:00
PHST- 2018/11/13 00:00 [received]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/08/22 06:00 [entrez]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
PHST- 2019/08/20 00:00 [pmc-release]
AID - 10.1038/s41598-019-48305-y [pii]
AID - 48305 [pii]
AID - 10.1038/s41598-019-48305-y [doi]
PST - epublish
SO  - Sci Rep. 2019 Aug 20;9(1):12131. doi: 10.1038/s41598-019-48305-y.