PMID- 31432633 OWN - NLM STAT- MEDLINE DCOM- 20200226 LR - 20200226 IS - 2234-3814 (Electronic) IS - 2234-3806 (Print) IS - 2234-3806 (Linking) VI - 40 IP - 1 DP - 2020 Jan TI - Performance of Copeptin for Early Diagnosis of Acute Myocardial Infarction in an Emergency Department Setting. PG - 7-14 LID - 10.3343/alm.2020.40.1.7 [doi] AB - BACKGROUND: Rapid and accurate diagnosis of acute myocardial infarction (AMI) is critical for initiating effective treatment and achieving better prognosis. We investigated the performance of copeptin for early diagnosis of AMI, in comparison with creatine kinase myocardial band (CK-MB) and troponin I (TnI). METHODS: We prospectively enrolled 271 patients presenting with chest pain (within six hours of onset), suggestive of acute coronary syndrome, at an emergency department (ED). Serum CK-MB, TnI, and copeptin levels were measured. The diagnostic performance of CK-MB, TnI, and copeptin, alone and in combination, for AMI was assessed by ROC curve analysis by comparing the area under the curve (AUC). Sensitivity, specificity, negative predictive value, and positive predictive value of each marker were obtained, and the characteristics of each marker were analyzed. RESULTS: The patients were diagnosed as having ST elevation myocardial infarction (STEMI; N=43), non-ST elevation myocardial infarction (NSTEMI; N=25), unstable angina (N=78), or other diseases (N=125). AUC comparisons showed copeptin had significantly better diagnostic performance than TnI in patients with chest pain within two hours of onset (AMI: P=0.022,