PMID- 31433819 OWN - NLM STAT- MEDLINE DCOM- 20200303 LR - 20200303 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 14 IP - 8 DP - 2019 TI - CMR feature tracking in cardiac asymptomatic systemic sclerosis: Clinical implications. PG - e0221021 LID - 10.1371/journal.pone.0221021 [doi] LID - e0221021 AB - BACKGROUND: Impaired myocardial deformation has been sporadically described in cardiac asymptomatic systemic sclerosis (SSc). We aimed to study myocardial deformation indices in cardiac asymptomatic SSc patients using cardiac magnetic resonance feature tracking (CMR-FT) and correlate these findings to the phenotypic and autoimmune background. METHODS: Fifty-four cardiac asymptomatic SSc patients (44 females, 56+/-13 years), with normal routine cardiac assessment and CMR evaluation, including cine and late gadolinium enhancement (LGE) images, were included. SSc patients were compared to 21 sex- and age- matched healthy controls (17 females; 54+/-19 years). For CMR-FT analysis, a mid-ventricular slice for LV peak systolic radial and circumferential strain and a 4-chamber view for LV/RV peak systolic longitudinal strain were used. RESULTS: Twenty-four patients had diffuse cutaneous SSc and 30 limited cutaneous SSc. Thirteen patients had digital ulcers. Median disease duration was 3.6 years. LV ejection fraction was higher in SSc patients compared to controls (62+/-6% vs. 59+/-5%, p = 0.01). Four patients had no LGE examination; in the remaining patients LGE was absent in 74%, while 18% had RV insertion fibrosis and 8% evidence of subendocardial infarction. LV longitudinal strain differed in those with insertion fibrosis (-18.0%) and infarction (-16.7%) compared to no fibrosis (-20.3%, p = 0.04). Patients with SSc had lower RV longitudinal strain and strain rate compared to controls (p<0.001 and p = 0.01, respectively). All other strain and strain rate measurements were non-significant between patients and controls. CONCLUSIONS: In cardiac asymptomatic SSc patients with normal routine functional indices, CMR-FT identifies subclinical presence of insertion fibrosis and/or myocardial infarction by impaired LV longitudinal strain. RV derived longitudinal indices were impaired in the patient group. CMR FT indices did not correlate to the patients' phenotypic and autoimmune features. FAU - Bratis, Konstantinos AU - Bratis K AD - CMR Unit, Onassis Cardiac Surgery Centre, Athens, Greece. FAU - Lindholm, Anthony AU - Lindholm A AD - Department of Clinical Sciences, Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden. FAU - Hesselstrand, Roger AU - Hesselstrand R AD - Department of Clinical Sciences, Rheumatology, Skane University Hospital, Lund University, Lund, Sweden. FAU - Arheden, Hakan AU - Arheden H AD - Department of Clinical Sciences, Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden. FAU - Karabela, Georgia AU - Karabela G AD - Naval Hospital, Athens, Greece. FAU - Stavropoulos, Efthymios AU - Stavropoulos E AD - Naval Hospital, Athens, Greece. FAU - Katsifis, Gikas AU - Katsifis G AD - Naval Hospital, Athens, Greece. FAU - Kolovou, Genovefa AU - Kolovou G AD - CMR Unit, Onassis Cardiac Surgery Centre, Athens, Greece. FAU - Kitas, George D AU - Kitas GD AD - Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom. FAU - Sfikakis, Petros P AU - Sfikakis PP AD - First Department of Propeudeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece. FAU - Koutsogeorgopoulou, Loukia AU - Koutsogeorgopoulou L AD - Pathophysiology Department, Laikon Hospital, Athens, Greece. FAU - Mavrogeni, Sophie AU - Mavrogeni S AD - CMR Unit, Onassis Cardiac Surgery Centre, Athens, Greece. FAU - Ostenfeld, Ellen AU - Ostenfeld E AD - Department of Clinical Sciences, Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20190821 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Aged MH - Contrast Media/*administration & dosage MH - Female MH - Fibrosis MH - Gadolinium/*administration & dosage MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - *Myocardial Infarction/diagnostic imaging/physiopathology MH - *Scleroderma, Diffuse/diagnostic imaging/physiopathology MH - *Ventricular Function, Left PMC - PMC6703686 COIS- The authors have declared that no competing interests exist. EDAT- 2019/08/23 06:00 MHDA- 2020/03/04 06:00 PMCR- 2019/08/21 CRDT- 2019/08/22 06:00 PHST- 2018/10/23 00:00 [received] PHST- 2019/07/30 00:00 [accepted] PHST- 2019/08/22 06:00 [entrez] PHST- 2019/08/23 06:00 [pubmed] PHST- 2020/03/04 06:00 [medline] PHST- 2019/08/21 00:00 [pmc-release] AID - PONE-D-18-30597 [pii] AID - 10.1371/journal.pone.0221021 [doi] PST - epublish SO - PLoS One. 2019 Aug 21;14(8):e0221021. doi: 10.1371/journal.pone.0221021. eCollection 2019.