PMID- 31433823
OWN - NLM
STAT- MEDLINE
DCOM- 20200303
LR  - 20201213
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 8
DP  - 2019
TI  - Cardiovascular magnetic resonance feature tracking strain analysis for 
      discrimination between hypertensive heart disease and hypertrophic 
      cardiomyopathy.
PG  - e0221061
LID - 10.1371/journal.pone.0221061 [doi]
LID - e0221061
AB  - BACKGROUND: Hypertensive heart disease (HHD) and hypertrophic cardiomyopathy 
      (HCM) are both associated with an increased left ventricular (LV) wall thickness. 
      Whilst LV ejection fraction is frequently normal in both, LV strain assessment 
      could differentiate between the diseases. We sought to establish if 
      cardiovascular magnetic resonance myocardial feature tracking (CMR-FT), an 
      emerging method allowing accurate assessment of myocardial deformation, 
      differentiates between both diseases. Additionally, CMR assessment of fibrosis 
      and LV hypertrophy allowed association analyses and comparison of diagnostic 
      capacities. METHODS: Two-hundred twenty-four consecutive subjects (53 HHD, 107 
      HCM, and 64 controls) underwent 1.5T CMR including native myocardial T1 mapping 
      and late gadolinium enhancement (LGE). Global longitudinal strain (GLS) was 
      assessed by CMR-FT (CVi42, Circle Cardiovascular Imaging Inc.). RESULTS: GLS was 
      significantly higher in HCM patients (-14.7+/-3.8 vs. -16.5+/-3.3% [HHD], P = 0.004; 
      or vs. -17.2+/-2.0% [controls], P<0.001). GLS was associated with LV mass index 
      (HHD, R = 0.419, P = 0.002; HCM, R = 0.429, P<0.001), and LV ejection fraction 
      (HHD, R = -0.493, P = 0.002; HCM, R = -0.329, P<0.001). In HCM patients, GLS was 
      also associated with global native T1 (R = 0.282, P = 0.003), and LGE volume (rho = 
      0.380, P<0.001). Discrimination between HHD and HCM by GLS (c = 0.639, 95% 
      confidence interval [CI] 0.550-0.729) was similar to LV mass index (c = 0.643, 
      95% CI 0.556-0.731), global myocardial native T1 (c = 0.718, 95% CI 0.638-0.799), 
      and LGE volume (c = 0.680, 95% CI 0.585-0.775). CONCLUSION: CMR-FT GLS 
      differentiates between HHD and HCM. In HCM patients GLS is associated with 
      myocardial fibrosis. The discriminatory capacity of CMR-FT GLS is similar to LV 
      hypertrophy and fibrosis imaging markers.
FAU - Neisius, Ulf
AU  - Neisius U
AUID- ORCID: 0000-0003-4744-9166
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Myerson, Lana
AU  - Myerson L
AUID- ORCID: 0000-0002-4844-6517
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Fahmy, Ahmed S
AU  - Fahmy AS
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Nakamori, Shiro
AU  - Nakamori S
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - El-Rewaidy, Hossam
AU  - El-Rewaidy H
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Joshi, Gargi
AU  - Joshi G
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Duan, Chong
AU  - Duan C
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Manning, Warren J
AU  - Manning WJ
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
AD  - Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, MA, United States of America.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
LA  - eng
GR  - R01 HL127015/HL/NHLBI NIH HHS/United States
GR  - R01 HL129157/HL/NHLBI NIH HHS/United States
GR  - R01 HL129185/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190821
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/physiopathology
MH  - Female
MH  - Fibrosis
MH  - *Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - *Hypertension/diagnostic imaging/physiopathology
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Stroke Volume
MH  - *Ventricular Function, Left
PMC - PMC6703851
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/08/23 06:00
MHDA- 2020/03/04 06:00
PMCR- 2019/08/21
CRDT- 2019/08/22 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/22 06:00 [entrez]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/03/04 06:00 [medline]
PHST- 2019/08/21 00:00 [pmc-release]
AID - PONE-D-19-10554 [pii]
AID - 10.1371/journal.pone.0221061 [doi]
PST - epublish
SO  - PLoS One. 2019 Aug 21;14(8):e0221061. doi: 10.1371/journal.pone.0221061. 
      eCollection 2019.