PMID- 31433838
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 153
IP  - 1
DP  - 2020 Jan 1
TI  - An Uncommon Case of Double-Hit Mantle Cell Lymphoma That Demonstrates a 
      Transformation Process.
PG  - 49-57
LID - 10.1093/ajcp/aqz133 [doi]
AB  - OBJECTIVES: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized 
      by CCND1/IGH rearrangement. We reported a case of MCL harboring both CCND1/IGH 
      and MYC/IGH rearrangements that also presented with an aggressive clinical 
      course. METHODS: Biopsy specimens were evaluated by morphological staining, 
      immunohistochemistry, flow cytometry, conventional cytogenetics, fluorescence in 
      situ hybridization (FISH), and next-generation sequencing (NGS). RESULTS: 
      Morphological and immunohistochemical staining of gallbladder samples 
      demonstrated blastoid variant MCL. However, in the bone marrow sample, FISH 
      indicated rearrangements in CCND1/IGH and MYC/IGH. Flow cytometry identified two 
      groups of malignant lymphocytes. We sorted these two groups of cells. NGS then 
      revealed that both cell types carried CCND1/IGH rearrangements and TP53 
      mutations. Furthermore, the CD19+/CD10+ cells carried additional MYC/IGH 
      rearrangement and NOTCH2 mutation. CONCLUSIONS: The rearrangement of MYC and a 
      mutation in NOTCH2 probably induced the transformation of MCL cells in this 
      patient. This uncommon double-hit MCL case clearly demonstrates a transformation 
      process.
CI  - (c) American Society for Clinical Pathology, 2019. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Zhou, Jihao
AU  - Zhou J
AD  - Department of Hematology, Second Clinical Medical College of Jinan University, 
      Shenzhen People's Hospital, Shenzhen, China.
FAU - Hu, Lina
AU  - Hu L
AD  - Department of Hematology, Second Clinical Medical College of Jinan University, 
      Shenzhen People's Hospital, Shenzhen, China.
FAU - Zuo, Min
AU  - Zuo M
AD  - Department of Pathology, Second Clinical Medical College of Jinan University, 
      Shenzhen People's Hospital, Shenzhen, China.
FAU - Zhou, Yaying
AU  - Zhou Y
AD  - Clinical Medicine Research Center, First Affiliated Hospital of Southern 
      University of Science and Technology, Second Clinical Medical College of Jinan 
      University, Shenzhen People's Hospital, Shenzhen, China.
FAU - Li, Guoqiang
AU  - Li G
AD  - Department of Hematology, Second Clinical Medical College of Jinan University, 
      Shenzhen People's Hospital, Shenzhen, China.
FAU - Zhang, Xinyou
AU  - Zhang X
AD  - Department of Hematology, Second Clinical Medical College of Jinan University, 
      Shenzhen People's Hospital, Shenzhen, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (CCND1 protein, human)
RN  - 0 (IGH-CCND1 fusion protein, human)
RN  - 0 (MYC protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Cell Transformation, Neoplastic
MH  - Cyclin D1/*genetics
MH  - Cytogenetics
MH  - Fatal Outcome
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/diagnostic imaging/genetics/*pathology
MH  - Lymphoma, Mantle-Cell/diagnostic imaging/genetics/*pathology/therapy
MH  - Middle Aged
MH  - Mutation
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Proto-Oncogene Proteins c-myc/*genetics
OTO - NOTNLM
OT  - Double-hit
OT  - Mantle cell lymphoma
OT  - Transformation
EDAT- 2019/08/23 06:00
MHDA- 2020/05/12 06:00
CRDT- 2019/08/22 06:00
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/08/22 06:00 [entrez]
AID - 5552734 [pii]
AID - 10.1093/ajcp/aqz133 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2020 Jan 1;153(1):49-57. doi: 10.1093/ajcp/aqz133.