PMID- 31434111
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1476-4245 (Electronic)
IS  - 1475-4916 (Linking)
VI  - 108
IP  - 4
DP  - 2019 Nov
TI  - A Placebo-Controlled Double-Blind Randomized Trial with Individualized 
      Homeopathic Treatment Using a Symptom Cluster Approach in Women with Premenstrual 
      Syndrome.
PG  - 256-269
LID - 10.1055/s-0039-1691834 [doi]
AB  - BACKGROUND: In a double-blind placebo-controlled randomized trial with parallel 
      groups, the efficacy of individually prescribed homeopathic medicines was 
      evaluated in women with premenstrual syndrome (PMS). METHODS: In an outpatient 
      department of a university clinic in Jerusalem, Israel (1996-1999), women with 
      PMS, aged 18 to 50 years, entered a 2-month screening phase with prospective 
      daily recording of premenstrual symptoms by the Menstrual Distress Questionnaire 
      (MDQ). They were included after being diagnosed with PMS. A reproducible 
      treatment protocol was used: women received a homeopathic prescription based on 
      symptom clusters identified in a questionnaire. The symptoms were verified during 
      a complementary, structured, interview. Only women whose symptoms matched the 
      symptom profile of one of 14 pre-selected homeopathic medicines were included. 
      Each participant was administered active medicine or placebo via random 
      allocation. Primary outcome measures were differences in changes in mean daily 
      premenstrual symptom (PM) scores by the MDQ. Analysis was by intention-to-treat. 
      RESULTS: A total of 105 women were included: 49 were randomized to active 
      medicine and 56 to placebo. Forty-three women in the active medicine group and 53 
      in the placebo group received the allocated intervention with at least one 
      follow-up measurement and their data were analyzed. Significantly greater 
      improvement of mean PM scores was measured in the active medicine group (0.443 
      [standard deviation, SD, 0.32] to 0.287 [SD, 0.20]) compared to placebo (0.426 
      [SD, 0.34] to 0.340 [SD, 0.39]); p = 0.043. CONCLUSIONS: Individually prescribed 
      homeopathic medicines were associated with significantly greater improvement of 
      PM scores in women with PMS, compared to placebo. Replication, with larger sample 
      size and other refinements, is recommended to confirm the efficacy of this 
      treatment in other settings.
CI  - The Faculty of Homeopathy.
FAU - Yakir, Michal
AU  - Yakir M
AD  - Israeli Association for Classical Homeopathy, Tel Aviv, Israel.
FAU - Klein-Laansma, Christien T
AU  - Klein-Laansma CT
AD  - Louis Bolk Institute, Health and Nutrition, Bunnik, The Netherlands.
FAU - Kreitler, Shulamith
AU  - Kreitler S
AD  - Psycho-oncology Research Center, Sheba Medical Center, Tel HaShomer, Israel.
FAU - Brzezinski, Amnon
AU  - Brzezinski A
AD  - Hadassah University Hospital, Jerusalem, Israel.
FAU - Oberbaum, Menachem
AU  - Oberbaum M
AD  - The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, 
      Jerusalem, Israel.
FAU - Vithoulkas, George
AU  - Vithoulkas G
AD  - International Homeopathic Academy, Allonisos, Greece.
FAU - Bentwich, Zvi
AU  - Bentwich Z
AD  - Rosetta Genomics, Rehovot, Israel.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190821
PL  - Germany
TA  - Homeopathy
JT  - Homeopathy : the journal of the Faculty of Homeopathy
JID - 101140517
SB  - IM
MH  - Adult
MH  - Double-Blind Method
MH  - Female
MH  - Homeopathy/*methods
MH  - Humans
MH  - Middle Aged
MH  - Precision Medicine/*methods
MH  - Premenstrual Syndrome/*therapy
MH  - Surveys and Questionnaires
MH  - Young Adult
COIS- The authors declare that no competing financial interests exist. Dr. 
      Klein-Laansma reports personal fees from Deutsche Homoopathische-Union (DHU), 
      Karlsruhe, Germany, outside the submitted work.
EDAT- 2019/08/23 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/08/22 06:00
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/08/22 06:00 [entrez]
AID - 10.1055/s-0039-1691834 [doi]
PST - ppublish
SO  - Homeopathy. 2019 Nov;108(4):256-269. doi: 10.1055/s-0039-1691834. Epub 2019 Aug 
      21.