PMID- 31434390
OWN - NLM
STAT- MEDLINE
DCOM- 20190905
LR  - 20190906
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 99
IP  - 28
DP  - 2019 Jul 23
TI  - [Efficacy of nasal CPAP and aerobic exercise of different intensity in patients 
      with obstructive sleep apnea hypopnea syndrome and type 2 diabetes mellitus].
PG  - 2187-2192
LID - 10.3760/cma.j.issn.0376-2491.2019.28.007 [doi]
AB  - Objective: To explore the therapeutic efficacy of nasal Continuous Positive 
      Airway Pressure (CPAP) and aerobic exercise of different intensity in patients 
      with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Type 2 Diabetes 
      Mellitus (T2DM). Methods: A total of 112 patients with OSAHS and T2DM, including 
      53 males and 59 females, with a mean age of (66.9+/-7.8) years old, from the Fourth 
      Rehabilitation Hospital of Shanghai and the Second Affiliated Hospital of Soochow 
      University from January 2017 to December 2018 were enrolled prospectively. There 
      were divided into two groups based on whether received nasal CPAP therapy: 50 
      cases in nasal CPAP+aerobic exercise group and 62 cases in aerobic exercise 
      group. Subsequently, patients in nasal CPAP+aerobic exercise group were randomly 
      divided into two subgroups: moderate and low intensity aerobic exercise (26 and 
      24 cases respectively). All patients completed nasal CPAP and (or) aerobic 
      exercise of different intensity for 20 weeks. The therapeutic efficacy of 
      polysomnography (PSG) parameters, glycolipid metabolism, 6 minutes walking 
      distance (6 MWD), and rate of perceived exertion (RPE) were compared between each 
      group before and after treatment. Results: Pre-and post-intervention, PSG 
      parameters, body mass index (BMI) [(26.6+/-3.7) vs (24.3+/-2.8) kg/m(2)], RPE 
      [(16.4+/-1.3) vs (12.2+/-2.6) score], 6 MWD [(372.6+/-59.7) vs (441.5+/-75.6) m] and 
      glucolipid metabolism indexes were improved significantly in nasal CPAP+aerobic 
      exercise group (all P<0.05), such as fasting blood glucose [(7.4+/-2.4) vs 
      (6.2+/-1.6) mmol/L], glycosylated hemoglobin [(7.6+/-1.2)% vs (6.6+/-0.7)%], fasting 
      insulin [(10.8+/-4.4) vs (6.9+/-3.4) muU/L], insulin resistance index [(3.5+/-1.9) vs 
      (1.9+/-1.2)], total cholesterol [(4.0+/-0.9) vs (3.5+/-0.9) mmol/L], low density 
      lipoprotein cholesterol [(4.2+/-0.6) vs (3.1+/-0.8) mmol/L]; BMI, exercise endurance, 
      some glucolipid metabolism indexes and PSG parameters were also improved in 
      aerobic exercise group (P<0.05). After 20 weeks' intervention, it showed 
      statistically significant differences in PSG parameters, glycometabolism, some 
      lipid metabolism indexes and RPE (all P<0.05), and no significantly difference in 
      BMI [(24.3+/-2.7) vs (24.3+/-2.8) kg/m(2)] between the two groups. Compared with the 
      low intensity subgroup, there were significant improvement in 2 hours' 
      postprandial insulin, insulin resistance index, low density lipoprotein 
      cholesterol, lipoprotein A, RPE, 6 MWD in moderate subgroup (P<0.05). Conclusion: 
      Nasal CPAP combined with moderate intensity aerobic exercise can effectively 
      improve the glucolipid metabolism, insulin resistance and exercise tolerance in 
      patients with OSAHS and T2DM.
FAU - Shen, H H
AU  - Shen HH
AD  - Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow 
      University, Suzhou 215004, China.
FAU - Xu, Y M
AU  - Xu YM
AD  - Department of Respiratory Rehabilitation, the Fourth Rehabilitation Hospital of 
      Shanghai, Shanghai 200042, China.
FAU - Wang, N
AU  - Wang N
AD  - Department of Respiratory Rehabilitation, the Fourth Rehabilitation Hospital of 
      Shanghai, Shanghai 200042, China.
FAU - Wang, J
AU  - Wang J
AD  - Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow 
      University, Suzhou 215004, China.
FAU - Ren, L
AU  - Ren L
AD  - Department of Respiratory Rehabilitation, the Fourth Rehabilitation Hospital of 
      Shanghai, Shanghai 200042, China.
FAU - Chen, R
AU  - Chen R
AD  - Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow 
      University, Suzhou 215004, China.
LA  - chi
GR  - 81770085/National Natural Science Foundation of China/
GR  - LCZX201604/Suzhou Special Project of Diagnosis and Therapeutics for Clinical Key 
      Diseases/
GR  - KJS1759/The open project of Jiangsu Key Laboratory of Preventive and 
      Translational Medicine for Geriatric Diseases/
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Aged
MH  - China
MH  - Continuous Positive Airway Pressure
MH  - *Diabetes Mellitus, Type 2
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Sleep Apnea, Obstructive
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Continuous positive airway pressure
OT  - Diabetes mellitus, type 2
OT  - Sleep apnea, obstructive
EDAT- 2019/08/23 06:00
MHDA- 2019/09/07 06:00
CRDT- 2019/08/23 06:00
PHST- 2019/08/23 06:00 [entrez]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2019.28.007 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2019 Jul 23;99(28):2187-2192. doi: 
      10.3760/cma.j.issn.0376-2491.2019.28.007.