PMID- 31434456
OWN - NLM
STAT- MEDLINE
DCOM- 20191008
LR  - 20191008
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 41
IP  - 8
DP  - 2019 Aug 23
TI  - [Clinicopathologic features of secretory breast carcinoma].
PG  - 628-632
LID - 10.3760/cma.j.issn.0253-3766.2019.08.013 [doi]
AB  - Objective: Investigate the clinicopathological features for secretory carcinoma 
      of breast (SCB). Methods: The clinical data of 3 SCB cases were collected, 
      immunohistochemical staining was performed by the streptavidin-peroxidase (SP) 
      method to test the expression of the antibodies: ER, PR, HER-2, Ki-67, S100, 
      CK5/6, p63, SMA, calponin, GCDFP-15, and EGFR. Fluorescence in situ hybridization 
      (FISH) was used to detect the ETV6-NTRK3 gene fusion. Results: ER was focal 
      weakly positive in case 1 and case 2 (about 5%) , and negative in case 3. PR was 
      focal weakly positive in case 1 (about 5%) and completely negative in case 2 and 
      case 3. Three cases showed that HER-2, SMA, calponin, GCDFP-15 were negative, 
      while S100, CK5/6, EGFR were diffuse strongly positive. The proliferation index 
      was nearly 15% in case 1 and case 2, and 10% in case 3. p63 was negative in 
      mostly tumor cells of case 1, and focal positive expression in the nucleus and 
      cytoplasm. In case 2, p63 was completely negative. However, p63 was observed 
      positive in the cytoplasm as well as some secretory material in case 3. 
      ETV6-NTRK3 gene fusion detection by FISH was positive in all cases. Conclusions: 
      SCB is a rare low grade triple-negative breast cancer with the unique 
      pathomorphologic features, while its recurrent t (12; 15) (p13; q25) 
      translocation resulting in ETV6 -NTRK3 gene fusion. It has the indolent clinical 
      behavior and good prognosis.
FAU - Zhang, F
AU  - Zhang F
AD  - Department of Pathology, SiChuan Cancer Hospital, ChengDu 610041, China.
FAU - Shi, M
AU  - Shi M
FAU - Liao, Q
AU  - Liao Q
FAU - Zhou, C M
AU  - Zhou CM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - Secretory breast carcinoma
SB  - IM
MH  - Breast Neoplasms/*pathology
MH  - Carcinoma/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
OTO - NOTNLM
OT  - ETS variant gene 6-neurotrophic tyrosine receptor kinase 3 gene
OT  - Pathology
OT  - Secretory carcinoma, breast
EDAT- 2019/08/23 06:00
MHDA- 2019/10/09 06:00
CRDT- 2019/08/23 06:00
PHST- 2019/08/23 06:00 [entrez]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2019/10/09 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-3766.2019.08.013 [doi]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2019 Aug 23;41(8):628-632. doi: 
      10.3760/cma.j.issn.0253-3766.2019.08.013.