PMID- 31435014
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20240204
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 572
IP  - 7771
DP  - 2019 Aug
TI  - Microbiota-derived lantibiotic restores resistance against vancomycin-resistant 
      Enterococcus.
PG  - 665-669
LID - 10.1038/s41586-019-1501-z [doi]
AB  - Intestinal commensal bacteria can inhibit dense colonization of the gut by 
      vancomycin-resistant Enterococcus faecium (VRE), a leading cause of 
      hospital-acquired infections(1,2). A four-strained consortium of commensal 
      bacteria that contains Blautia producta BP(SCSK) can reverse antibiotic-induced 
      susceptibility to VRE infection(3). Here we show that BP(SCSK) reduces growth of 
      VRE by secreting a lantibiotic that is similar to the nisin-A produced by 
      Lactococcus lactis. Although the growth of VRE is inhibited by BP(SCSK) and L. 
      lactis in vitro, only BP(SCSK) colonizes the colon and reduces VRE density in 
      vivo. In comparison to nisin-A, the BP(SCSK) lantibiotic has reduced activity 
      against intestinal commensal bacteria. In patients at high risk of VRE infection, 
      high abundance of the lantibiotic gene is associated with reduced density of E. 
      faecium. In germ-free mice transplanted with patient-derived faeces, resistance 
      to VRE colonization correlates with abundance of the lantibiotic gene. 
      Lantibiotic-producing commensal strains of the gastrointestinal tract reduce 
      colonization by VRE and represent potential probiotic agents to re-establish 
      resistance to VRE.
FAU - Kim, Sohn G
AU  - Kim SG
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
AD  - Weill Cornell Medical College, New York, NY, USA.
FAU - Becattini, Simone
AU  - Becattini S
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Moody, Thomas U
AU  - Moody TU
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Shliaha, Pavel V
AU  - Shliaha PV
AD  - Microchemistry and Proteomics Core Laboratory, Sloan Kettering Institute, 
      Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Littmann, Eric R
AU  - Littmann ER
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Seok, Ruth
AU  - Seok R
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Gjonbalaj, Mergim
AU  - Gjonbalaj M
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Eaton, Vincent
AU  - Eaton V
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Fontana, Emily
AU  - Fontana E
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Amoretti, Luigi
AU  - Amoretti L
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Wright, Roberta
AU  - Wright R
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Caballero, Silvia
AU  - Caballero S
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
AD  - Weill Cornell Medical College, New York, NY, USA.
FAU - Wang, Zhong-Min X
AU  - Wang ZX
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Jung, Hea-Jin
AU  - Jung HJ
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
FAU - Morjaria, Sejal M
AU  - Morjaria SM
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, NY, USA.
FAU - Leiner, Ingrid M
AU  - Leiner IM
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Qin, Weige
AU  - Qin W
AD  - Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering 
      Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Ramos, Ruben J J F
AU  - Ramos RJJF
AD  - Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering 
      Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Cross, Justin R
AU  - Cross JR
AD  - Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan Kettering 
      Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Narushima, Seiko
AU  - Narushima S
AD  - RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
FAU - Honda, Kenya
AU  - Honda K
AD  - RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
AD  - JSR-Keio University Medical and Chemical Innovation Center, Tokyo, Japan.
AD  - RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
FAU - Peled, Jonathan U
AU  - Peled JU
AD  - Weill Cornell Medical College, New York, NY, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Hendrickson, Ronald C
AU  - Hendrickson RC
AD  - Microchemistry and Proteomics Core Laboratory, Sloan Kettering Institute, 
      Memorial Sloan Kettering Cancer Center, New York, NY, USA.
AD  - Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Taur, Ying
AU  - Taur Y
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, NY, USA.
FAU - van den Brink, Marcel R M
AU  - van den Brink MRM
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA.
AD  - Weill Cornell Medical College, New York, NY, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Pamer, Eric G
AU  - Pamer EG
AD  - Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer 
      Center, New York, NY, USA. egpamer@uchicago.edu.
AD  - Weill Cornell Medical College, New York, NY, USA. egpamer@uchicago.edu.
AD  - Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA. egpamer@uchicago.edu.
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, NY, USA. egpamer@uchicago.edu.
LA  - eng
GR  - U01 AI124275/AI/NIAID NIH HHS/United States
GR  - T34 GM007823/GM/NIGMS NIH HHS/United States
GR  - S10 OD010598/OD/NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - R01 AI095706/AI/NIAID NIH HHS/United States
GR  - R01 AI042135/AI/NIAID NIH HHS/United States
GR  - T32 GM007739/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190821
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bacteriocins)
RN  - 1414-45-5 (Nisin)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/biosynthesis/isolation & 
      purification/metabolism/pharmacology
MH  - Bacteriocins/genetics/isolation & purification/*metabolism/*pharmacology
MH  - Enterococcus faecium/*drug effects/growth & development/isolation & purification
MH  - Feces/microbiology
MH  - Female
MH  - Gastrointestinal Tract/drug effects/microbiology
MH  - Germ-Free Life
MH  - Gram-Positive Bacteria/drug effects/growth & development
MH  - Humans
MH  - Lactococcus lactis/chemistry/growth & development/*metabolism/physiology
MH  - Mice
MH  - Microbial Sensitivity Tests
MH  - Microbiota/genetics
MH  - Nisin/chemistry/pharmacology
MH  - *Probiotics
MH  - Symbiosis/drug effects
MH  - Vancomycin/pharmacology
MH  - Vancomycin Resistance/*drug effects
MH  - Vancomycin-Resistant Enterococci/*drug effects/growth & development/isolation & 
      purification
PMC - PMC6717508
MID - NIHMS1535496
EDAT- 2019/08/23 06:00
MHDA- 2020/02/26 06:00
PMCR- 2020/02/21
CRDT- 2019/08/23 06:00
PHST- 2018/10/22 00:00 [received]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/08/23 06:00 [entrez]
PHST- 2020/02/21 00:00 [pmc-release]
AID - 10.1038/s41586-019-1501-z [pii]
AID - 10.1038/s41586-019-1501-z [doi]
PST - ppublish
SO  - Nature. 2019 Aug;572(7771):665-669. doi: 10.1038/s41586-019-1501-z. Epub 2019 Aug 
      21.