PMID- 31435914
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20201123
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2059
DP  - 2020
TI  - An Overview of Drug Delivery Systems.
PG  - 1-54
LID - 10.1007/978-1-4939-9798-5_1 [doi]
AB  - This is an overview of the current drug delivery systems (DDSs) starting with 
      various routes of drug administration. Various drug formulations are then 
      described as well as devices used for drug delivery and targeted drug delivery. 
      There has been a considerable increase in the number of new biotechnology-based 
      therapeutics. Most of these are proteins and peptides, and their delivery present 
      special challenges. Cell and gene therapies are sophisticated methods of delivery 
      of therapeutics. Nanoparticles are important for refining drug delivery. In 
      addition to being vehicles for drug delivery, nanoparticles can be used as 
      pharmaceuticals as well as diagnostics. Most of the advances in targeted drug 
      delivery have occurred in therapy of cancer. Drug delivery to the brain across 
      the blood-brain barrier presents many challenges. Refinements in drug delivery 
      will facilitate the development of personalized medicine. The ideal DDS is 
      defined. Commercial aspects, challenges, and future of DDSs are discussed.
FAU - Jain, Kewal K
AU  - Jain KK
AD  - Jain PharmaBiotech, Basel, Switzerland. jain@pharmabiotech.ch.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Peptides)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Brain/*drug effects/metabolism
MH  - Delayed-Action Preparations/therapeutic use
MH  - Drug Administration Routes
MH  - Drug Compounding/methods
MH  - Drug Delivery Systems/instrumentation/*methods
MH  - Drug Therapy, Combination/methods
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Nanoparticles/chemistry/therapeutic use
MH  - Neoplasms/*drug therapy/immunology/metabolism
MH  - Peptides/administration & dosage/chemistry/pharmacology/therapeutic use
MH  - Pharmaceutical Preparations/administration & dosage/chemistry/metabolism
MH  - Precision Medicine/*methods
OTO - NOTNLM
OT  - Cell therapy
OT  - Controlled release
OT  - Drug delivery devices
OT  - Drug delivery systems
OT  - Drug formulations
OT  - Gene therapy
OT  - Nanoparticles
OT  - Personalized medicine
OT  - Protein/peptide delivery
OT  - Routes of drug administration
OT  - Targeted drug delivery
EDAT- 2019/08/23 06:00
MHDA- 2020/11/24 06:00
CRDT- 2019/08/23 06:00
PHST- 2019/08/23 06:00 [entrez]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
AID - 10.1007/978-1-4939-9798-5_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2020;2059:1-54. doi: 10.1007/978-1-4939-9798-5_1.