PMID- 31435932
OWN - NLM
STAT- MEDLINE
DCOM- 20191121
LR  - 20200108
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 99
IP  - 15
DP  - 2019 Dec
TI  - Silkworm dropping extract regulates food allergy symptoms via inhibition of 
      Th2-related responses in an ovalbumin-induced food allergy model.
PG  - 7008-7015
LID - 10.1002/jsfa.9993 [doi]
AB  - BACKGROUND: Silkworm droppings have long been used in traditional medicine to 
      remedy allergic itching, palsy, blood circulation problems, and arthritis in 
      Asian countries. To investigate the anti-allergic effect of silkworm dropping 
      extract (SDE) and its mechanism, we used a mouse model of food allergy induced by 
      ovalbumin (OVA). RESULTS: SDE ameliorated the symptoms of OVA-induced food 
      allergies, and the levels of T helper 2 (Th2)-related cytokines [such as 
      interleukin (IL)-4, IL-5, IL-10, and IL-13] were found to be significantly 
      decreased in both the spleen and mesenteric lymph nodes by SDE. Furthermore, SDE 
      treatment directly inhibited OVA permeation, IL-4 production, and degranulation 
      of mast cells; in contrast, immunoglobulin E (IgE) production from B cells was 
      not affected. CONCLUSION: These results suggest that SDE has potential 
      anti-allergic activities, and SDE may be useful in the treatment/prevention of 
      allergic disorders such as food allergies, serving as therapeutic agents. (c) 2019 
      Society of Chemical Industry.
CI  - (c) 2019 Society of Chemical Industry.
FAU - Jung, Sun Young
AU  - Jung SY
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
AD  - Food Biotechnology Program, Korea University of Science and Technology, Daejeon, 
      Republic of Korea.
FAU - See, Hye-Joeng
AU  - See HJ
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
FAU - Kwon, Da-Ae
AU  - Kwon DA
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
FAU - Choi, Dae-Woon
AU  - Choi DW
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
AD  - Food Biotechnology Program, Korea University of Science and Technology, Daejeon, 
      Republic of Korea.
FAU - Lee, So-Young
AU  - Lee SY
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
AD  - Food Biotechnology Program, Korea University of Science and Technology, Daejeon, 
      Republic of Korea.
FAU - Shon, Dong-Hwa
AU  - Shon DH
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
AD  - Department of Food Processing and Distribution, Gangneung-Wonju National 
      University, Gangneung, Gangwon-do, Republic of Korea.
FAU - Shin, Hee Soon
AU  - Shin HS
AUID- ORCID: 0000-0002-0942-7161
AD  - Division of Nutrition and Metabolism Research, Korea Food Research Institute, 
      Wanju-gun, Jeollabuk-do, Republic of Korea.
AD  - Food Biotechnology Program, Korea University of Science and Technology, Daejeon, 
      Republic of Korea.
LA  - eng
GR  - E0170400-03/Korea Food Research Institute/
PT  - Journal Article
DEP - 20191008
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-5)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*administration & dosage/chemistry
MH  - Bombyx/*chemistry
MH  - Feces/*chemistry
MH  - Female
MH  - Food Hypersensitivity/*drug therapy/genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Interleukin-13/genetics/immunology
MH  - Interleukin-4/genetics/immunology
MH  - Interleukin-5/genetics/immunology
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/adverse effects
MH  - Th2 Cells/*drug effects/immunology
OTO - NOTNLM
OT  - Th2-related cytokines
OT  - food allergy
OT  - immunoglobulin E
OT  - silkworm dropping
EDAT- 2019/08/23 06:00
MHDA- 2019/11/22 06:00
CRDT- 2019/08/23 06:00
PHST- 2018/07/06 00:00 [received]
PHST- 2019/03/04 00:00 [revised]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2019/11/22 06:00 [medline]
PHST- 2019/08/23 06:00 [entrez]
AID - 10.1002/jsfa.9993 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2019 Dec;99(15):7008-7015. doi: 10.1002/jsfa.9993. Epub 2019 
      Oct 8.