PMID- 31437744
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20200512
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 130
IP  - 10
DP  - 2019 Oct
TI  - Lack of evidence for interhemispheric inhibition in the lower face primary motor 
      cortex.
PG  - 1917-1925
LID - S1388-2457(19)31182-4 [pii]
LID - 10.1016/j.clinph.2019.07.027 [doi]
AB  - OBJECTIVE: To investigate interhemispheric inhibition (IHI) between the facial 
      primary motor cortices (fM1s). METHODS: IHI was investigated in 10 healthy 
      subjects using paired-pulse TMS in the depressor anguli oris (DAO), upper 
      trapezius (UT) and first dorsal interosseous (FDI) muscles. Conditioning stimuli 
      (CS) of 90-130% resting motor threshold (RMT) preceded test motor evoked 
      potentials (MEPs) by 7 interstimulus intervals (ISIs) ranging 4-12 ms. In the 
      DAO, we also examined IHI at 1-2 ms ISIs. RESULTS: IHI was detected in the UT (CS 
      130% RMT; ISI 8 ms; p = 0.02) and FDI (CS 120% and 130% RMT, at 8-10 ms ISIs; 
      p = 0.004), but not in DAO at any ISI, instead, there was facilitation at 1-4 ms 
      ISIs and 110-130% RMT CS. In the DAO, conditioned responses at 1-4 ms ISIs were 
      significantly larger than both test MEPs and the response induced by the CS 
      alone. CONCLUSION: In the DAO there was no evidence of IHI even though this was 
      clear in hand and axial muscles. Control experiments excluded a transcallosal 
      origin of the facilitation observed at the shortest intervals. SIGNIFICANCE: Data 
      suggest that integrated bilateral control of facial muscles occurs mainly at the 
      level of brainstem circuits engaged by corticobulbar output from fM1.
CI  - Copyright (c) 2019 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Ginatempo, Francesca
AU  - Ginatempo F
AD  - Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 
      07100 Sassari, Italy.
FAU - Manzo, Nicoletta
AU  - Manzo N
AD  - IRCCS NEUROMED, Pozzilli, IS, Italy.
FAU - Rothwell, John C
AU  - Rothwell JC
AD  - Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of 
      Neurology, London, UK.
FAU - Deriu, Franca
AU  - Deriu F
AD  - Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 
      07100 Sassari, Italy. Electronic address: deriuf@uniss.it.
LA  - eng
PT  - Journal Article
DEP - 20190808
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Facial Muscles/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Hand/physiology
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/*physiology
MH  - Transcranial Magnetic Stimulation/methods
OTO - NOTNLM
OT  - Brainstem
OT  - Corpus callosum
OT  - Face primary motor cortex
OT  - Facial muscles
OT  - IHI
OT  - Interhemispheric inhibition
EDAT- 2019/08/23 06:00
MHDA- 2020/05/13 06:00
CRDT- 2019/08/23 06:00
PHST- 2019/02/27 00:00 [received]
PHST- 2019/07/01 00:00 [revised]
PHST- 2019/07/17 00:00 [accepted]
PHST- 2019/08/23 06:00 [pubmed]
PHST- 2020/05/13 06:00 [medline]
PHST- 2019/08/23 06:00 [entrez]
AID - S1388-2457(19)31182-4 [pii]
AID - 10.1016/j.clinph.2019.07.027 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2019 Oct;130(10):1917-1925. doi: 10.1016/j.clinph.2019.07.027. 
      Epub 2019 Aug 8.