PMID- 31439643
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20201101
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 68
IP  - 11
DP  - 2019 Nov
TI  - White Matter Microstructural Change Contributes to Worse Cognitive Function in 
      Patients With Type 2 Diabetes.
PG  - 2085-2094
LID - 10.2337/db19-0233 [doi]
AB  - Patients with type 2 diabetes mellitus (T2DM) have a considerably high risk of 
      developing dementia, especially for those with mild cognitive impairment (MCI). 
      The investigation of the microstructural change of white matter (WM) between T2DM 
      with amnesic MCI (T2DM-aMCI) and T2DM with normal cognition (T2DM-NC) and their 
      relationships to cognitive performances can help to understand the brain 
      variations in T2DM-related amnesic cognitive impairment. In the current study, 36 
      T2DM-aMCI patients, 40 T2DM-NC patients, and 40 healthy control (HC) individuals 
      underwent diffusion tensor image and T1-weighted MRI scans and comprehensive 
      cognition assessments. All of these cognitive functions exhibited intergroup 
      ranking differences in patients. The T2DM-NC patients and HC individuals did not 
      reveal any significant differences in WM integrity. The T2DM-aMCI patients showed 
      disrupted integrity in multiple WM tracts compared with HC and T2DM-NC. 
      Specifically, the damaged WM integrity of the right inferior fronto-occipital 
      fasciculus and the right inferior longitudinal fasciculus exhibited significant 
      correlations with episodic memory and attention function impairment in T2DM 
      patients. Furthermore, cognitive impairment-related WM microstructural damage was 
      associated with the degeneration of cortex connected to the affected WM tract. 
      These findings indicate that degeneration exists extensively in WM tracts in 
      T2DM-aMCI, whereas no brain WM damage is evident in T2DM-NC.
CI  - (c) 2019 by the American Diabetes Association.
FAU - Gao, Shudan
AU  - Gao S
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Chen, Yaojing
AU  - Chen Y
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Sang, Feng
AU  - Sang F
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Yang, Yiru
AU  - Yang Y
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Xia, Jianan
AU  - Xia J
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Li, Xin
AU  - Li X
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
FAU - Zhang, Junying
AU  - Zhang J
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Traditional 
      Chinese Medicine, Beijing, People's Republic of China.
FAU - Chen, Kewei
AU  - Chen K
AD  - Banner Alzheimer's Institute, Phoenix, AZ.
FAU - Zhang, Zhanjun
AU  - Zhang Z
AUID- ORCID: 0000-0001-7266-4218
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, People's Republic of China zhang_rzs@bnu.edu.cn.
AD  - Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, 
      Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190822
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
MH  - Aged
MH  - Cognition
MH  - Cognition Disorders/*diagnostic imaging/etiology
MH  - Diabetes Complications/*diagnostic imaging/etiology
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic imaging
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - White Matter/*diagnostic imaging
PMC - PMC6804632
EDAT- 2019/08/24 06:00
MHDA- 2020/03/18 06:00
PMCR- 2020/11/01
CRDT- 2019/08/24 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/08/15 00:00 [accepted]
PHST- 2019/08/24 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2019/08/24 06:00 [entrez]
PHST- 2020/11/01 00:00 [pmc-release]
AID - db19-0233 [pii]
AID - 0233 [pii]
AID - 10.2337/db19-0233 [doi]
PST - ppublish
SO  - Diabetes. 2019 Nov;68(11):2085-2094. doi: 10.2337/db19-0233. Epub 2019 Aug 22.