PMID- 31441357 OWN - NLM STAT- MEDLINE DCOM- 20200914 LR - 20210110 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 8 IP - 17 DP - 2019 Sep 3 TI - Early Left Ventricular Involvement Detected by Cardiovascular Magnetic Resonance Feature Tracking in Arrhythmogenic Right Ventricular Cardiomyopathy: The Effects of Left Ventricular Late Gadolinium Enhancement and Right Ventricular Dysfunction. PG - e012989 LID - 10.1161/JAHA.119.012989 [doi] LID - e012989 AB - Background Left ventricular (LV) involvement is common in arrhythmogenic right ventricular cardiomyopathy (ARVC). We aim to evaluate LV involvement in ARVC patients by cardiovascular magnetic resonance feature tracking. Methods and Results Sixty-eight patients with ARVC and 30 controls were prospectively enrolled. ARVC patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group (LVEF >/=55%, n=27) and the reduced LVEF group (LVEF <55%, n=41). Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) and cardiovascular magnetic resonance feature tracking were performed in all subjects. LV global and regional (basal, mid, apical) peak strain (PS) in radial, circumferential and longitudinal directions were assessed, respectively. Right ventricular global PS in three directions were also analyzed. Compared with the controls, LV global and regional PS were all significantly impaired in the reduced LVEF group (all P<0.05). However, only LV global longitudinal PS as well as mid and apical longitudinal PS were impaired in the preserved LVEF group (all P<0.05), and all these parameters were significantly associated with right ventricular global radial PS (r=-0.47, -0.47, and -0.49, respectively, all P<0.001). The reduced LVEF group showed significantly higher prevalence of LGE (95.10% versus 63.00%, P=0.002) than the preserved LVEF group. Moreover, LV radial PS was significantly reduced in LV segments with LGE (33.15+/-20.42%, n=46) than those without LGE (41.25+/-15.98%, n=386) in the preserved LVEF group (P=0.016). Conclusions In patients with ARVC, cardiovascular magnetic resonance feature tracking could detect early LV dysfunction, which was associated with LV myocardial LGE and right ventricular dysfunction. FAU - Chen, Xiuyu AU - Chen X AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Li, Lu AU - Li L AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Cheng, Huaibin AU - Cheng H AD - Department of Function Test Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Song, Yanyan AU - Song Y AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Ji, Keshan AU - Ji K AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Chen, Lin AU - Chen L AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Han, Tongtong AU - Han T AD - Circle Cardiovascular Imaging Inc. Calgary Alberta Canada. FAU - Lu, Minjie AU - Lu M AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. FAU - Zhao, Shihua AU - Zhao S AD - Department of CMR State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190823 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Arrhythmogenic Right Ventricular Dysplasia/complications/*diagnostic imaging/physiopathology MH - Case-Control Studies MH - Contrast Media/*administration & dosage MH - Early Diagnosis MH - Female MH - Gadolinium DTPA/*administration & dosage MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Prospective Studies MH - Reproducibility of Results MH - *Stroke Volume MH - Time Factors MH - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology MH - Ventricular Dysfunction, Right/*diagnostic imaging/etiology/physiopathology MH - *Ventricular Function, Left MH - *Ventricular Function, Right MH - Young Adult PMC - PMC6755833 OTO - NOTNLM OT - arrhythmogenic right ventricular dysplasia OT - magnetic resonance imaging OT - strain OT - ventricle EDAT- 2019/08/24 06:00 MHDA- 2020/09/15 06:00 PMCR- 2019/09/03 CRDT- 2019/08/24 06:00 PHST- 2019/08/24 06:00 [entrez] PHST- 2019/08/24 06:00 [pubmed] PHST- 2020/09/15 06:00 [medline] PHST- 2019/09/03 00:00 [pmc-release] AID - JAH34328 [pii] AID - 10.1161/JAHA.119.012989 [doi] PST - ppublish SO - J Am Heart Assoc. 2019 Sep 3;8(17):e012989. doi: 10.1161/JAHA.119.012989. Epub 2019 Aug 23.