PMID- 31441890 OWN - NLM STAT- MEDLINE DCOM- 20190903 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 98 IP - 34 DP - 2019 Aug TI - Association between the persistent organic pollutants and polycystic ovary syndrome: A protocol for a systematic review and meta-analysis. PG - e16948 LID - 10.1097/MD.0000000000016948 [doi] LID - e16948 AB - BACKGROUND: Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS. METHODS: Databases including PubMed, Embase, Web of Science, and CNKI will be searched to identify qualified studies. All qualified studies regarding the association between POPs and PCOS will be included. The primary outcome of the present study is POPs levels in serum of subjects. Pooled analysis with corresponding 95% confidence intervals will be performed. RESULTS: The comprehensive analysis and quantitative assessment will provide a better understanding of POPs concentrations in patients with PCOS. CONCLUSION: This meta-analysis and systematic review will generate evidence of the association between POPs and PCOS. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019126373. FAU - Li, Yan AU - Li Y AD - First Affiliated Hospital, Heilongjiang University of Chinese Medicine. FAU - Zhang, Mei-Wei AU - Zhang MW AD - First Affiliated Hospital, Heilongjiang University of Chinese Medicine. FAU - Wang, Ying-Ji AU - Wang YJ AD - College of Pharmacy, Harbin Medical University, Harbin, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Environmental Pollutants) SB - IM MH - Environmental Pollutants/*poisoning MH - Female MH - Humans MH - Meta-Analysis as Topic MH - Polycystic Ovary Syndrome/*etiology MH - Systematic Reviews as Topic PMC - PMC6716724 COIS- The authors have no conflicts of interest to disclose. EDAT- 2019/08/24 06:00 MHDA- 2019/09/04 06:00 PMCR- 2019/08/23 CRDT- 2019/08/24 06:00 PHST- 2019/08/24 06:00 [entrez] PHST- 2019/08/24 06:00 [pubmed] PHST- 2019/09/04 06:00 [medline] PHST- 2019/08/23 00:00 [pmc-release] AID - 00005792-201908230-00056 [pii] AID - MD-D-19-05853 [pii] AID - 10.1097/MD.0000000000016948 [doi] PST - ppublish SO - Medicine (Baltimore). 2019 Aug;98(34):e16948. doi: 10.1097/MD.0000000000016948.