PMID- 31442336
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20200227
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 29
IP  - 12
DP  - 2019 Dec
TI  - Effects of exercising before breakfast on the health of T2DM patients-A 
      randomized controlled trial.
PG  - 1930-1936
LID - 10.1111/sms.13543 [doi]
AB  - This is the first study to examine whether training before breakfast in the 
      overnight-fasted state is more effective in improving the health of patients with 
      type 2 diabetes mellitus (T2DM) than after breakfast in the fed state. Thirty 
      T2DM patients (60 +/- 8 years, 33.7 +/- 4.6 kg/m(2) ) were randomly assigned to the F 
      group (training in the overnight-fasted state (n = 15)) and to the C group 
      (training in the fed state (control group, n = 15)). All patients completed an 
      8-week combined endurance/strength training program. Physical training 
      significantly increased time to physical exhaustion during an endurance test 
      (+10.4%), power output during strength tests (chest presses: +36.7% and seated 
      rows: +37.8%), and fat-free mass (+1.7 kg). Body fat mass (-1.9 kg), glycated 
      hemoglobin (HbA1c) values (absolute change: -0.3%), serum insulin values 
      (-2.5 microU/mL), the homeostatic model assessment for insulin resistance 
      (HOMA-IR) index (-1.1), and circulating triglyceride levels (-31 mg/dL) decreased 
      significantly from pre- to post-training. The training had no effect on body mass 
      index, serum fasting glucose, total cholesterol, low-density 
      lipoprotein/high-density lipoprotein ratio or interleukin (IL)-6, IL-10 and tumor 
      necrosis factor (TNF)alpha levels. Analyses of variance revealed no time x group 
      interaction for any variable (P > .05). The training was effective in improving 
      the health of T2DM patients. However, the preliminary study's data do not provide 
      any evidence that the nutritional state (overnight-fasted or fed) in regular 
      physical training plays a significant role for training-induced adaptations in 
      T2DM patients. Full trials (using other training protocols as well) should be 
      conducted to gain further knowledge about the relevance of pre-exercise breakfast 
      ingestion.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Brinkmann, Christian
AU  - Brinkmann C
AUID- ORCID: 0000-0001-8419-7565
AD  - IST University of Applied Sciences, Dusseldorf, Germany.
AD  - Institute of Cardiovascular Research and Sport Medicine, Department of Preventive 
      and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, 
      Germany.
FAU - Weh-Gray, Olivier
AU  - Weh-Gray O
AD  - Institute of Cardiovascular Research and Sport Medicine, Department of Molecular 
      and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Brixius, Klara
AU  - Brixius K
AD  - Institute of Cardiovascular Research and Sport Medicine, Department of Molecular 
      and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Bloch, Wilhelm
AU  - Bloch W
AD  - Institute of Cardiovascular Research and Sport Medicine, Department of Molecular 
      and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Predel, Hans-Georg
AU  - Predel HG
AD  - Institute of Cardiovascular Research and Sport Medicine, Department of Preventive 
      and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, 
      Germany.
FAU - Kreutz, Thorsten
AU  - Kreutz T
AD  - IST University of Applied Sciences, Dusseldorf, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190909
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
SB  - IM
MH  - Aged
MH  - Blood Glucose
MH  - Body Mass Index
MH  - *Breakfast
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/*blood/therapy
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Physical Endurance
MH  - *Resistance Training
MH  - Time Factors
OTO - NOTNLM
OT  - T2DM
OT  - exercise
OT  - fasted state
OT  - overnight fasting
OT  - training
OT  - type 2 diabetes
EDAT- 2019/08/24 06:00
MHDA- 2020/02/28 06:00
CRDT- 2019/08/24 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/08/19 00:00 [accepted]
PHST- 2019/08/24 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2019/08/24 06:00 [entrez]
AID - 10.1111/sms.13543 [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2019 Dec;29(12):1930-1936. doi: 10.1111/sms.13543. Epub 
      2019 Sep 9.