PMID- 31443530
OWN - NLM
STAT- MEDLINE
DCOM- 20200609
LR  - 20211204
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 9
IP  - 9
DP  - 2019 Aug 22
TI  - Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis 
      Development after Ischemic Acute Kidney Injury.
LID - 10.3390/biom9090404 [doi]
LID - 404
AB  - Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a 
      combination of several mechanisms. We recently demonstrated that fasting protects 
      the rat kidney against oxidative stress and mitochondrial dysfunction in early 
      acute kidney injury, and also against fibrosis development. Here we show that 
      preoperative fasting preserves redox status and mitochondrial homeostasis at the 
      chronic phase of damage after severe ischemia. Also, the protective effect of 
      fasting coincides with the suppression of inflammation and endoplasmic reticulum 
      stress, as well as the down-regulation of the mechanistic target of rapamycin 
      (mTOR) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways 
      in the fibrotic kidney. Our results demonstrate that fasting targets multiple 
      pathophysiological mechanisms to prevent renal fibrosis and damage that results 
      after renal ischemia-reperfusion injury.
FAU - Rojas-Morales, Pedro
AU  - Rojas-Morales P
AD  - Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico.
FAU - Tapia, Edilia
AU  - Tapia E
AD  - Departamento de Fisiopatologia Cardio-Renal, Instituto Nacional de Cardiologia 
      Ignacio Chavez, Ciudad de Mexico 14080, Mexico.
FAU - Leon-Contreras, Juan Carlos
AU  - Leon-Contreras JC
AD  - Departamento de Patologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      Salvador Zubiran, Ciudad de Mexico 14080, Mexico.
FAU - Gonzalez-Reyes, Susana
AU  - Gonzalez-Reyes S
AD  - Laboratorio de Bioquimica, Facultad de Medicina y Psicologia, Universidad 
      Nacional Autonoma de Baja California, Tijuana 22390, Mexico.
FAU - Jimenez-Osorio, Angelica Sarai
AU  - Jimenez-Osorio AS
AD  - Laboratorio de Medicina Genomica, Hospital Regional Lic. Adolfo Lopez Mateos, 
      ISSSTE, Ciudad de Mexico 01030, Mexico.
FAU - Trujillo, Joyce
AU  - Trujillo J
AD  - Consejo Nacional de Ciencia y Tecnologia-Consorcio de Investigacion, Innovacion y 
      Desarrollo para las Zonas Aridas- Instituto Potosino de Investigacion Cientifica 
      y Tecnologica, San Luis Potosi 78216, Mexico.
FAU - Pavon, Natalia
AU  - Pavon N
AD  - Departamento de Farmacologia, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Ciudad de Mexico 14080, Mexico.
FAU - Granados-Pineda, Jessica
AU  - Granados-Pineda J
AUID- ORCID: 0000-0002-1921-1663
AD  - Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico.
FAU - Hernandez-Pando, Rogelio
AU  - Hernandez-Pando R
AD  - Departamento de Patologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      Salvador Zubiran, Ciudad de Mexico 14080, Mexico.
FAU - Sanchez-Lozada, Laura Gabriela
AU  - Sanchez-Lozada LG
AUID- ORCID: 0000-0003-0348-9617
AD  - Departamento de Fisiopatologia Cardio-Renal, Instituto Nacional de Cardiologia 
      Ignacio Chavez, Ciudad de Mexico 14080, Mexico.
FAU - Osorio-Alonso, Horacio
AU  - Osorio-Alonso H
AUID- ORCID: 0000-0002-9238-4202
AD  - Departamento de Fisiopatologia Cardio-Renal, Instituto Nacional de Cardiologia 
      Ignacio Chavez, Ciudad de Mexico 14080, Mexico.
FAU - Pedraza-Chaverri, Jose
AU  - Pedraza-Chaverri J
AUID- ORCID: 0000-0001-6628-4411
AD  - Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico. pedraza@unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190822
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Acute Kidney Injury/metabolism/*pathology/*prevention & control
MH  - Animals
MH  - *Fasting
MH  - Fibrosis
MH  - Kidney/metabolism/*pathology
MH  - Male
MH  - Mitochondria/pathology
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/metabolism/*pathology/*prevention & control
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC6770803
OTO - NOTNLM
OT  - ER stress
OT  - fasting
OT  - fibrosis
OT  - inflammation
OT  - ischemia-reperfusion injury
OT  - mitochondrial dysfunction
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/25 06:00
MHDA- 2020/06/10 06:00
PMCR- 2019/09/01
CRDT- 2019/08/25 06:00
PHST- 2019/06/13 00:00 [received]
PHST- 2019/08/15 00:00 [revised]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/08/25 06:00 [entrez]
PHST- 2019/08/25 06:00 [pubmed]
PHST- 2020/06/10 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - biom9090404 [pii]
AID - biomolecules-09-00404 [pii]
AID - 10.3390/biom9090404 [doi]
PST - epublish
SO  - Biomolecules. 2019 Aug 22;9(9):404. doi: 10.3390/biom9090404.