PMID- 31444626
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20220218
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 476
IP  - 3
DP  - 2020 Mar
TI  - Renal cell tumors with an entrapped papillary component: a collision with 
      predilection for oncocytic tumors.
PG  - 399-407
LID - 10.1007/s00428-019-02648-z [doi]
AB  - Renal cell tumors with mixed morphology resembling multiple renal cell carcinoma 
      (RCC) subtypes are generally regarded as unclassified RCC. However, occasionally, 
      papillary adenoma or RCC appears admixed with a larger, different tumor 
      histology. We retrieved 17 renal tumors containing a papillary adenoma or 
      papillary RCC component admixed with another tumor histology and studied them 
      with immunohistochemistry and fluorescence in situ hybridization (FISH). Larger 
      tumors were oncocytomas (n = 10), chromophobe RCCs (n = 5), borderline oncocytic 
      tumor (n = 1), and clear cell RCC (n = 1). The size of papillary component ranged 
      from 1 to 34 mm. One tumor was an oncocytoma encircled by a cyst (2.0 cm) with 
      papillary hyperplasia of the lining. The papillary lesions were diffusely 
      cytokeratin 7 positive (17/17), in contrast to "host" tumors. 
      Alpha-methylacyl-coA-racemase labeling was usually stronger in the papillary 
      lesions (13/15). KIT was negative in all papillary lesions and the clear cell RCC 
      and positive in 16/16 oncocytic or chromophobe tumors. Eight of 15 (53%) 
      collision tumors had differing FISH results in the two components. A papillary 
      renal cell proliferation within another tumor is an uncommon phenomenon with 
      predilection for oncocytoma and chromophobe RCC, possibly related to their common 
      entrapment of benign tubules. When supported by distinct morphology and 
      immunohistochemistry in these two components, this phenomenon should be diagnosed 
      as a collision of two processes. A diagnosis of unclassified RCC should be 
      avoided, due to potential misrepresentation as an aggressive renal cancer.
FAU - Williamson, Sean R
AU  - Williamson SR
AUID- ORCID: 0000-0002-3898-1460
AD  - Department of Pathology and Laboratory Medicine and Henry Ford Cancer Institute, 
      Henry Ford Health System, Detroit, MI, USA. williamson.sean@outlook.com.
AD  - Department of Pathology, Wayne State University School of Medicine, Detroit, MI, 
      USA. williamson.sean@outlook.com.
FAU - Cheng, Liang
AU  - Cheng L
AUID- ORCID: 0000-0001-6049-5293
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Gadde, Ramya
AU  - Gadde R
AD  - Department of Pathology and Laboratory Medicine and Henry Ford Cancer Institute, 
      Henry Ford Health System, Detroit, MI, USA.
FAU - Giannico, Giovanna A
AU  - Giannico GA
AD  - Department of Pathology, Microbiology, and Immunology, Vanderbilt University 
      Medical Center, Nashville, TN, USA.
FAU - Wasco, Matthew J
AU  - Wasco MJ
AD  - Department of Pathology, St. Joseph Mercy Hospital, Ann Arbor, MI, USA.
FAU - Taylor Smith, Paul J
AU  - Taylor Smith PJ
AD  - Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive 
      Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
FAU - Gupta, Nilesh S
AU  - Gupta NS
AD  - Department of Pathology and Laboratory Medicine and Henry Ford Cancer Institute, 
      Henry Ford Health System, Detroit, MI, USA.
FAU - Grignon, David J
AU  - Grignon DJ
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Jorda, Merce
AU  - Jorda M
AD  - Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive 
      Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
AD  - Department of Urology, University of Miami Miller School of Medicine, Miami, FL, 
      USA.
FAU - Kryvenko, Oleksandr N
AU  - Kryvenko ON
AD  - Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive 
      Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
AD  - Department of Urology, University of Miami Miller School of Medicine, Miami, FL, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20190823
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - Oncocytoma, renal
SB  - IM
MH  - Adenoma/*pathology
MH  - Adenoma, Oxyphilic/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carcinoma, Renal Cell/pathology
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Multiple Primary/*pathology
OTO - NOTNLM
OT  - Collision tumor
OT  - Oncocytoma
OT  - Papillary adenoma
OT  - Renal cell carcinoma
EDAT- 2019/08/25 06:00
MHDA- 2020/03/31 06:00
CRDT- 2019/08/25 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/08/13 00:00 [accepted]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/08/25 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2019/08/25 06:00 [entrez]
AID - 10.1007/s00428-019-02648-z [pii]
AID - 10.1007/s00428-019-02648-z [doi]
PST - ppublish
SO  - Virchows Arch. 2020 Mar;476(3):399-407. doi: 10.1007/s00428-019-02648-z. Epub 
      2019 Aug 23.