PMID- 31444965
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 32
IP  - 9
DP  - 2019 Sep 25
TI  - Association between inflammation, oxidative stress, vitamin D, copper and zinc 
      with pre-obesity and obesity in school children from the city of Podgorica, 
      Montenegro.
PG  - 951-957
LID - 10.1515/jpem-2019-0086 [doi]
AB  - Background Childhood obesity is a serious health condition with increasing rates 
      worldwide. The aim of this study was to investigate the association between 
      inflammation, oxidative stress, vitamin D, copper and zinc in pre-obese and obese 
      children compared to controls. Methods The study involved 202 children aged 7-15 
      years (63.9% boys), randomly chosen from 10 elementary schools in Podgorica, 
      Montenegro. Participants were divided into three groups according to their 
      nutritional status (International Obesity Task Force [IOTF] criteria): 
      normal-weight (42.1%), pre-obese (40.6%) and obese (17.3%). Serum biochemical 
      analyses were performed (C-reactive protein [CRP], retinol-binding protein [RBP], 
      total antioxidant status [TAS], total vitamin D [VD], copper and zinc). Results 
      Serum TAS and CRP concentrations were higher in pre-obese and obese children 
      compared to controls (p < 0.001). Serum VD concentrations were lower in pre-obese 
      and obese children compared to their normal-weight peers (p = 0.027 and 
      p = 0.054, respectively). Copper, zinc and RBP concentrations did not differ 
      significantly among the groups (p > 0.05). In pre-obese and obese children, a 
      positive correlation was found between CRP and copper (r = 0.305, p = 0.011 and 
      r = 0.440, p = 0.013, respectively), and TAS and RBP (r = 0.528, p < 0.001 and 
      r = 0.434, p = 0.015, respectively). Standard regression analyses showed that CRP 
      and TAS increase (p < 0.001) whereas VD decreases (p = 0.011) with the body mass 
      index (BMI). Conclusions We show that pre-obesity and obesity in childhood are 
      positively associated with oxidative stress and inflammation, and inversely 
      associated with VD status. Copper and zinc concentrations were not associated 
      with excess fat in children.
FAU - Jaksic, Marina
AU  - Jaksic M
AD  - Institute for Children's Diseases, Department of Laboratory Diagnostics, 
      Podgorica, Montenegro.
FAU - Martinovic, Milica
AU  - Martinovic M
AD  - Faculty of Medicine, Department for Pathophysiology and Laboratory Medicine, 
      University of Montenegro, Podgorica, Montenegro.
FAU - Gligorovic-Barhanovic, Najdana
AU  - Gligorovic-Barhanovic N
AD  - Center for Laboratory Diagnostics, Clinical Center of Montenegro, Podgorica, 
      Montenegro.
FAU - Vujacic, Aleksandar
AU  - Vujacic A
AD  - Center for Human Ecology, Department of Sanitary Chemistry, Institute of Public 
      Health, Podgorica, Montenegro.
FAU - Djurovic, Dijana
AU  - Djurovic D
AD  - Center for Human Ecology, Department of Sanitary Chemistry, Institute of Public 
      Health, Podgorica, Montenegro.
FAU - Nedovic-Vukovic, Mirjana
AU  - Nedovic-Vukovic M
AD  - Center for Health System Development, Department of Health Statistics and 
      Informatics, Institute of Public Health, Podgorica, Montenegro.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
RN  - 789U1901C5 (Copper)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Antioxidants/metabolism
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Copper/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inflammation/*physiopathology
MH  - Male
MH  - Montenegro/epidemiology
MH  - *Oxidative Stress
MH  - Pediatric Obesity/blood/*epidemiology/pathology
MH  - Prognosis
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/*physiopathology
MH  - Vitamins/blood
MH  - Zinc/*blood
OTO - NOTNLM
OT  - inflammation
OT  - obesity
OT  - oligoelements
OT  - oxidative stress
OT  - vitamin D
EDAT- 2019/08/25 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/08/25 06:00
PHST- 2019/02/14 00:00 [received]
PHST- 2019/07/16 00:00 [accepted]
PHST- 2019/08/25 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/08/25 06:00 [entrez]
AID - /j/jpem.ahead-of-print/jpem-2019-0086/jpem-2019-0086.xml [pii]
AID - 10.1515/jpem-2019-0086 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2019 Sep 25;32(9):951-957. doi: 
      10.1515/jpem-2019-0086.