PMID- 31445835
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1532-8422 (Electronic)
IS  - 1053-0770 (Linking)
VI  - 34
IP  - 3
DP  - 2020 Mar
TI  - The Effect of Sedation on Long-Term Psychological Impairment After Extracorporeal 
      Life Support.
PG  - 663-667
LID - S1053-0770(19)30792-X [pii]
LID - 10.1053/j.jvca.2019.07.147 [doi]
AB  - OBJECTIVE: This retrospective study aimed to identify the association between 
      long-term psychological impairment and total sedation received during venovenous 
      extracorporeal life support (VV-ECLS) for acute respiratory failure (ARF). 
      DESIGN: This observational retrospective study compared characteristics between 
      patients with and without long-term psychological morbidity at long-term 
      follow-up after VV-ECLS for ARF. SETTING: A single institutional experience in a 
      quaternary referral academic medical center in the United States. PATIENTS: 
      Patients who received VV-ECLS for ARF between January 1, 2015, and April 1, 2017, 
      were identified for selection. Presence of psychiatric morbidity (anxiety and/or 
      depression) was determined with the Hospital Anxiety and Depression Subscale 
      battery at long-term follow-up. INTERVENTIONS: No interventions were made during 
      this retrospective observational study. MEASUREMENTS AND MAIN RESULTS: A total of 
      42 patients (21 male, 21 female, median age 49 [interquartile range IQR 36-57]) 
      completed a telephone interview a median of 14.6 (IQR 7.7-21.1) months after ECLS 
      decannulation. Cohorts were defined as possessing any psychiatric morbidity 
      (anxiety and/or depression) as defined by the Hospital Anxiety and Depression 
      Subscale battery (n = 22 [52%]) versus no psychiatric morbidity (n = 20 [48%]) at 
      long-term follow-up. Patients who had clinically significant psychiatric 
      morbidity received a median of 15.0 (IQR 11.0-17.0) days of continuous 
      intravenous sedation compared with patients who had no psychiatric morbidity, who 
      received a median of 10.0 (IQR 6.5-13.5) days of intravenous sedation; 
      (p = 0.02). CONCLUSIONS: This retrospective analysis identified a significant 
      association between the presence of long-term post-VV-ECLS psychiatric symptoms 
      and the total number of days of intravenous sedation.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - McDonald, Michael D
AU  - McDonald MD
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Lane-Fall, Meghan
AU  - Lane-Fall M
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA; Penn Center for Perioperative Outcomes Research and 
      Transformation, Philadelphia, PA.
FAU - Miano, Todd A
AU  - Miano TA
AD  - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of 
      Medicine at the University of Pennsylvania, Philadelphia, PA.
FAU - Henry, Madeline
AU  - Henry M
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Gallagher, Colby
AU  - Gallagher C
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Hadler, Rachel
AU  - Hadler R
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Laudanski, Krzysztof
AU  - Laudanski K
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Mackay, Emily J
AU  - Mackay EJ
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA; Penn Center for Perioperative Outcomes Research and 
      Transformation, Philadelphia, PA.
FAU - Usman, Asad A
AU  - Usman AA
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA.
FAU - Gutsche, Jacob
AU  - Gutsche J
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania Health 
      System, Philadelphia, PA. Electronic address: Jacob.Gutsche@uphs.upenn.edu.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190802
PL  - United States
TA  - J Cardiothorac Vasc Anesth
JT  - Journal of cardiothoracic and vascular anesthesia
JID - 9110208
SB  - IM
MH  - *Anesthesia
MH  - Anxiety/epidemiology
MH  - Child, Preschool
MH  - *Extracorporeal Membrane Oxygenation
MH  - Female
MH  - Humans
MH  - Male
MH  - *Respiratory Distress Syndrome
MH  - Retrospective Studies
OTO - NOTNLM
OT  - acute respiratory distress syndrome
OT  - acute respiratory failure
OT  - extracorporeal life support
OT  - extracorporeal membrane oxygenation
OT  - sedation
COIS- Declaration of Competing Interest The authors have no conflicts of interest to 
      disclose.
EDAT- 2019/08/26 06:00
MHDA- 2021/04/28 06:00
CRDT- 2019/08/26 06:00
PHST- 2019/05/06 00:00 [received]
PHST- 2019/07/25 00:00 [revised]
PHST- 2019/07/28 00:00 [accepted]
PHST- 2019/08/26 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2019/08/26 06:00 [entrez]
AID - S1053-0770(19)30792-X [pii]
AID - 10.1053/j.jvca.2019.07.147 [doi]
PST - ppublish
SO  - J Cardiothorac Vasc Anesth. 2020 Mar;34(3):663-667. doi: 
      10.1053/j.jvca.2019.07.147. Epub 2019 Aug 2.