PMID- 31445873
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20221214
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Print)
IS  - 0890-8567 (Linking)
VI  - 59
IP  - 8
DP  - 2020 Aug
TI  - Effects of Childhood and Adult Persistent Attention-Deficit/Hyperactivity 
      Disorder on Risk of Motor Vehicle Crashes: Results From the Multimodal Treatment 
      Study of Children With Attention-Deficit/Hyperactivity Disorder.
PG  - 952-963
LID - S0890-8567(19)31458-3 [pii]
LID - 10.1016/j.jaac.2019.08.007 [doi]
AB  - OBJECTIVE: To determine motor vehicle crash (MVC) risk in adults with a history 
      of childhood attention-deficit/hyperactivity disorder (ADHD) and persistent ADHD 
      symptoms. METHOD: Participants with (n = 441) and without (n = 239; local 
      normative comparison group) childhood ADHD from the Multimodal Treatment of 
      Attention-Deficit/Hyperactivity Disorder (MTA) Study were included. Participants 
      provided self-reports on total number of MVCs they had been involved in and the 
      time of licensure. Driving experience was estimated as the number of months since 
      licensure. Total number of MVCs by adulthood was regressed on baseline ADHD 
      status adjusting for sex, age at follow-up, driving experience, baseline 
      oppositional defiant disorder/conduct disorder comorbidity, baseline household 
      income level, adult oppositional defiant disorder/conduct disorder symptoms, 
      adolescent and adult substance use, and adult antisocial personality disorder 
      symptoms. We repeated the analysis using adult ADHD status (persistent versus 
      desistant versus local normative comparison group) and symptom level as the 
      predictor variables. Results are presented as incidence rate ratio (IRR) and CI. 
      RESULTS: Childhood ADHD was associated with a higher number of MVCs (IRR = 1.45, 
      CI = 1.15-1.82), and adult ADHD symptom persistence was associated with more MVCs 
      than desistance (IRR = 1.46, CI = 1.14-1.86). ADHD desistance was not associated 
      with a significantly increased risk for MVCs compared with the local normative 
      comparison group (IRR = 1.24, CI = 0.96-1.61). Concurrent symptoms of inattention 
      and hyperactivity/impulsivity predicted MVC risk. CONCLUSION: Persistence of ADHD 
      into adulthood is a stronger predictor of MVC risk than childhood-limited ADHD. 
      CLINICAL TRIAL REGISTRATION INFORMATION: Multimodal Treatment of Attention 
      Deficit Hyperactivity Disorder (MTA) Study; https://clinicaltrials.gov; 
      NCT00000388.
CI  - Copyright (c) 2019 American Academy of Child and Adolescent Psychiatry. All rights 
      reserved.
FAU - Roy, Arunima
AU  - Roy A
AD  - The Royal's Institute of Mental Health Research, University of Ottawa, Ontario, 
      Canada.
FAU - Garner, Annie A
AU  - Garner AA
AD  - Saint Louis University, St. Louis, Missouri.
FAU - Epstein, Jeffery N
AU  - Epstein JN
AD  - University of Cincinnati College of Medicine and the Division of Behavioral 
      Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, 
      Ohio.
FAU - Hoza, Betsy
AU  - Hoza B
AD  - University of Vermont, Burlington.
FAU - Nichols, J Quyen
AU  - Nichols JQ
AD  - University of Vermont, Burlington.
FAU - Molina, Brooke S G
AU  - Molina BSG
AD  - University of Pittsburgh School of Medicine, Pennsylvania.
FAU - Swanson, James M
AU  - Swanson JM
AD  - Child Development Center, School of Medicine, University of California, Irvine.
FAU - Arnold, L Eugene
AU  - Arnold LE
AD  - Nisonger Center, Ohio State University, Columbus.
FAU - Hechtman, Lily
AU  - Hechtman L
AD  - Division of Child Psychiatry, Montreal Children's Hospital, McGill University, 
      Quebec, Canada. Electronic address: lhechtman@hotmail.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT00000388
GR  - R01 DA039881/DA/NIDA NIH HHS/United States
GR  - U01 MH050461/MH/NIMH NIH HHS/United States
GR  - N01MH12009/MH/NIMH NIH HHS/United States
GR  - N01 DA085550/DA/NIDA NIH HHS/United States
GR  - N01MH12012/MH/NIMH NIH HHS/United States
GR  - N01 DA085554/DA/NIDA NIH HHS/United States
GR  - U01 MH050440/MH/NIMH NIH HHS/United States
GR  - N01MH12011/MH/NIMH NIH HHS/United States
GR  - N01 DA085551/DA/NIDA NIH HHS/United States
GR  - N01MH12007/MH/NIMH NIH HHS/United States
GR  - N01 DA085552/DA/NIDA NIH HHS/United States
GR  - U01 MH050453/MH/NIMH NIH HHS/United States
GR  - N01MH12004/MH/NIMH NIH HHS/United States
GR  - N01 DA085549/DA/NIDA NIH HHS/United States
GR  - U01 MH050467/MH/NIMH NIH HHS/United States
GR  - N01MH12010/MH/NIMH NIH HHS/United States
GR  - N01 DA085553/DA/NIDA NIH HHS/United States
GR  - N01MH12008/MH/NIMH NIH HHS/United States
GR  - N01 DA085548/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190822
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
CIN - J Am Acad Child Adolesc Psychiatry. 2020 Aug;59(8):923-925. PMID: 32147569
MH  - Accidents, Traffic
MH  - Adolescent
MH  - Adult
MH  - *Attention Deficit Disorder with Hyperactivity/epidemiology/therapy
MH  - Attention Deficit and Disruptive Behavior Disorders
MH  - Child
MH  - Combined Modality Therapy
MH  - Comorbidity
MH  - Humans
MH  - Motor Vehicles
PMC - PMC9747063
MID - NIHMS1856801
OTO - NOTNLM
OT  - ADHD persistence
OT  - attention-deficit/hyperactivity disorder (ADHD)
OT  - comorbidity
OT  - driving
OT  - motor vehicle crashes
EDAT- 2019/08/26 06:00
MHDA- 2021/03/19 06:00
PMCR- 2022/12/13
CRDT- 2019/08/26 06:00
PHST- 2018/09/14 00:00 [received]
PHST- 2019/07/22 00:00 [revised]
PHST- 2019/08/15 00:00 [accepted]
PHST- 2019/08/26 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2019/08/26 06:00 [entrez]
PHST- 2022/12/13 00:00 [pmc-release]
AID - S0890-8567(19)31458-3 [pii]
AID - 10.1016/j.jaac.2019.08.007 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2020 Aug;59(8):952-963. doi: 
      10.1016/j.jaac.2019.08.007. Epub 2019 Aug 22.