PMID- 31446192
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 245
DP  - 2020 Jan
TI  - Incidence of Splanchnic Vein Thrombosis After Abdominal Surgery: A Systematic 
      Review and Meta-analysis.
PG  - 500-509
LID - S0022-4804(19)30580-3 [pii]
LID - 10.1016/j.jss.2019.07.086 [doi]
AB  - BACKGROUND: Abdominal surgery may increase the risk of splanchnic vein thrombosis 
      (SVT). We determined the incidence of SVT after abdominal surgery and identified 
      groups at highest risk. MATERIALS AND METHODS: MEDLINE and Embase were searched 
      for clinical studies evaluating the incidence of postoperative SVT after 
      abdominopelvic surgery. Study selection, data abstraction, and risk of bias 
      assessment were carried out independently by two reviewers. Clinical 
      heterogeneity was explored by subgroup analyses (i.e., type of intra-abdominal 
      procedure and organ group). RESULTS: Of 5549 abstracts screened, 48 were 
      analyzed. Pooled incidence of SVT (n = 50,267) was 2.68% [95% confidence interval 
      (CI), 2.24 to 3.11] (1347 events), I(2) = 96%. Pooled incidence of SVT in 
      high-risk procedures were splenectomy with devascularization (24%), hepatectomy 
      in patients with cirrhosis (9%), and pancreatectomy with venous resection (5%). 
      Pooled incidence of symptomatic and asymptomatic SVT was 1.02% (95% CI: 0.97% to 
      1.07%) and 0.98% (95% CI 0.88% to 1.07%), respectively. Most common causes of 
      SVT-related mortality were irreversible thrombosis, bowel ischemia, liver 
      failure, and gastrointestinal bleed. Most studies included were at a high risk of 
      bias due to lack of prospective data collection and lack of SVT screening for all 
      participants. CONCLUSIONS: Incidence of SVT after abdominal surgery is low but 
      remains a relevant complication. Patients undergoing procedures involving 
      surgical manipulation of the venous system and splenectomy are at the highest 
      risk. Given the life-threatening risks associated with SVT, there is a need for 
      larger prospective studies on the incidence and impact of SVT after abdominal 
      surgery.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Zhang, Betty
AU  - Zhang B
AD  - DeGroote School of Medicine, McMaster University, Hamilton Ontario, Canada.
FAU - Kim, Minji
AU  - Kim M
AD  - Department of Surgery, McMaster University, Hamilton Ontario, Canada.
FAU - Griffiths, Christopher
AU  - Griffiths C
AD  - DeGroote School of Medicine, McMaster University, Hamilton Ontario, Canada.
FAU - Shi, Qian
AU  - Shi Q
AD  - DeGroote School of Medicine, McMaster University, Hamilton Ontario, Canada.
FAU - Duceppe, Emmanuelle
AU  - Duceppe E
AD  - Department of Medicine, University of Montreal, Montreal, Qeubec, Canada; Centre 
      de Recherche du Centre Hospitalier Universitaire de Montreal, Montreal, Qeubec, 
      Canada.
FAU - Ruo, Leyo
AU  - Ruo L
AD  - Department of Surgery, McMaster University, Hamilton Ontario, Canada.
FAU - Serrano, Pablo E
AU  - Serrano PE
AD  - Department of Surgery, McMaster University, Hamilton Ontario, Canada. Electronic 
      address: serrano@mcmaster.ca.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190822
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Abdominal Cavity/*surgery
MH  - Hepatectomy/adverse effects
MH  - Humans
MH  - Incidence
MH  - Pancreatectomy/adverse effects
MH  - Postoperative Complications/*epidemiology/etiology
MH  - Risk Factors
MH  - *Splanchnic Circulation
MH  - Splenectomy/adverse effects
MH  - Venous Thrombosis/*epidemiology/etiology
OTO - NOTNLM
OT  - Clinical presentation
OT  - Splanchnic vein thrombosis
EDAT- 2019/08/26 06:00
MHDA- 2020/02/15 06:00
CRDT- 2019/08/26 06:00
PHST- 2019/05/17 00:00 [received]
PHST- 2019/07/19 00:00 [revised]
PHST- 2019/07/21 00:00 [accepted]
PHST- 2019/08/26 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/08/26 06:00 [entrez]
AID - S0022-4804(19)30580-3 [pii]
AID - 10.1016/j.jss.2019.07.086 [doi]
PST - ppublish
SO  - J Surg Res. 2020 Jan;245:500-509. doi: 10.1016/j.jss.2019.07.086. Epub 2019 Aug 
      22.