PMID- 31447205
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200113
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1606
DP  - 2019 Nov 22
TI  - Qualitative screening and quantitative determination of 569 pesticide residues in 
      honeysuckle using ultrahigh-performance liquid chromatography coupled to 
      quadrupole-Orbitrap high resolution mass spectrometry.
PG  - 460374
LID - S0021-9673(19)30758-7 [pii]
LID - 10.1016/j.chroma.2019.460374 [doi]
AB  - A method for both qualitative screening and quantitative determination of 569 
      pesticides in honeysuckle was developed based on ultrahigh-performance liquid 
      chromatography (UHPLC) coupled to quadrupole-Orbitrap high resolution mass 
      spectrometry and an in-house executable compound database involving the 
      theoretical masses of precursor and fragment ions and retention times. Different 
      workflows were evaluated, validated and compared including Full MS-SIM, Full 
      MS/ddMS(2), Full MS/AIF and Full MS/DIA. For qualitative analysis, Full MS/DIA 
      showed relatively low screening detection limits (SDLs) for most pesticides, but 
      its MS(2) identification seemed to be not reliable enough. Full MS/ddMS(2) showed 
      good repeatability of fragment ion recognition and less false positives. For 
      quantitative analysis, the results of four workflows were comparable in terms of 
      linearity and trueness, while Full MS-SIM and Full MS/ddMS(2) gave better 
      precision than the other two workflows for most pesticides at the spiking level 
      of 0.01 mg/kg. Therefore, UHPLC-Full MS/ddMS(2) was considered as the optimal 
      workflow for both qualitative and quantitative analysis of honeysuckle samples. 
      Pesticides were present in 75 of the 82 investigated samples, with concentrations 
      ranging from 10.0 to 4116.9 mug/kg in some of the most severely contaminated 
      samples.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Zhou, Heng
AU  - Zhou H
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Cao, Yi-Min
AU  - Cao YM
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Miao, Shui
AU  - Miao S
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Lan, Lan
AU  - Lan L
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Chen, Ming
AU  - Chen M
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Li, Wen-Ting
AU  - Li WT
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Mao, Xiu-Hong
AU  - Mao XH
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
FAU - Ji, Shen
AU  - Ji S
AD  - Shanghai Institute for Food and Drug Control, Shanghai 201203, China. Electronic 
      address: jishen2013@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190716
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Pesticide Residues)
RN  - 0 (Pesticides)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Chromatography, Liquid
MH  - Databases, Chemical
MH  - Limit of Detection
MH  - Lonicera/*chemistry
MH  - Mass Spectrometry/*methods
MH  - Pesticide Residues/*analysis
MH  - Pesticides/analysis
OTO - NOTNLM
OT  - Honeysuckle
OT  - Pesticide residues
OT  - QuEChERS
OT  - Qualitative and quantitative analysis
OT  - UHPLC-Q-Orbitrap HRMS
EDAT- 2019/08/27 06:00
MHDA- 2020/01/14 06:00
CRDT- 2019/08/27 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/07/03 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/08/27 06:00 [entrez]
AID - S0021-9673(19)30758-7 [pii]
AID - 10.1016/j.chroma.2019.460374 [doi]
PST - ppublish
SO  - J Chromatogr A. 2019 Nov 22;1606:460374. doi: 10.1016/j.chroma.2019.460374. Epub 
      2019 Jul 16.