PMID- 31448453
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 12
DP  - 2019 Dec
TI  - LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-kappaB.
PG  - 19415-19421
LID - 10.1002/jcb.29119 [doi]
AB  - Accumulating studies have implicated that long noncoding RNA (lncRNA) plays a 
      vital role in lung cancer. However, little is known of the role of lncRNA highly 
      upregulated in liver cancer (HULC) in the pathogenesis of lung squamous cell 
      carcinoma (LSCC). In this study, we investigated the modifying effects and 
      underlying mechanisms of lncRNA HULC in LSCC. Significantly decreased level of 
      lncRNA HULC was observed in LSCC samples compared with adjacent tissues. Besides, 
      the expression of lncRNA HULC was negatively associated with protein tyrosine 
      phosphatase receptor type O (PTPRO) in LSCC. Moreover, lncRNA HULC could promote 
      the proliferation of LSCC cells by downregulating the expression PTPRO dependent 
      on the phosphorylation and activation of nuclear factor-kappaB (NF-kappaB). The present 
      study firstly shows strong evidence supporting a critical role of lncRNA HULC in 
      promoting LSCC by regulating PTPRO/NF-kappaB signaling pathway, which provides new 
      promising biomarkers for LSCC.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Xu, Yang
AU  - Xu Y
AD  - National Center of Occupational Safety and Health, NHC, Beijing, China.
FAU - Li, Jingyun
AU  - Li J
AD  - National Center of Occupational Safety and Health, NHC, Beijing, China.
FAU - Wang, Pingping
AU  - Wang P
AD  - Department of Gynecology and Obstetrics, Weifang Hospital of Maternal and Child 
      Health, Weifang, China.
FAU - Zhang, Zhenliang
AU  - Zhang Z
AD  - Department of Thoracic Surgery, the Affiliated Hospital of Weifang Medical 
      University, Weifang, China.
FAU - Wang, Xuetao
AU  - Wang X
AUID- ORCID: 0000-0002-9743-4678
AD  - National Center of Occupational Safety and Health, NHC, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190825
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (HULC long non-coding RNA, human)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Long Noncoding)
RN  - EC 3.1.3.48 (PTPRO protein, human)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blotting, Western
MH  - Carcinoma, Non-Small-Cell Lung/genetics/*metabolism/*pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics/physiology
MH  - Humans
MH  - Lung Neoplasms/genetics/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 3/genetics/*metabolism
OTO - NOTNLM
OT  - long noncoding RNA
OT  - lung cancer
OT  - nuclear factor-kappaB
OT  - protein tyrosine phosphatase receptor type O
EDAT- 2019/08/27 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/08/27 06:00
PHST- 2018/12/13 00:00 [received]
PHST- 2019/02/13 00:00 [revised]
PHST- 2019/02/21 00:00 [accepted]
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/08/27 06:00 [entrez]
AID - 10.1002/jcb.29119 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Dec;120(12):19415-19421. doi: 10.1002/jcb.29119. Epub 2019 
      Aug 25.