PMID- 314487
OWN - NLM
STAT- MEDLINE
DCOM- 19791128
LR  - 20211203
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 150
IP  - 3
DP  - 1979 Sep 19
TI  - Suppression of IgE antibody production in SJL mice. IV. Interaction of primed and 
      unprimed T cells.
PG  - 507-16
AB  - The mechanism of selective anti-hapten IgE antibody production was studied in SJL 
      mice. Using an adoptive transfer method of spleen cells into syngeneic recipients 
      irradiated with a sublethal dose of 600 rads, it was demonstrated that for the 
      suppression of anti-dinitrophenyl (DNP) IgE antibody production the interaction 
      of two subsets of T cells is necessary. DNP-primed B cells and carrier-primed T 
      helper cells are taken from donors primed with small amounts of DNP-carrier 
      conjugates. Without injection of other cells, high titer and persistent anti-DNP 
      antibodies are produced in the recipients. The two subsets of T cells that are 
      active in suppression of IgE are taken from two types of donors: one donor is 
      immunized (hyperprimed) with larger amounts of carrier protein twice, the other 
      is an unprimed donor. The carrier for hyperpriming the first type of donor may be 
      unrelated to the carrier used for priming the helper T cells. To bring about 
      anti-DNP IgE suppression it is necessary that the animals should be challenged 
      with the same DNP-carrier conjugate used for priming the B and T helper cells. If 
      the hyperprimed donors were immunized with a heterologous, unrelated carrier, 
      then this heterologous unconjugated carrier must also be injected together with 
      the homologous DNP-carrier conjugate. In these conditions, anti-DNP IgE antibody 
      production is suppressed, but the production of anti-DNP IgG1 antibody is not 
      diminished.
FAU - Itaya, T
AU  - Itaya T
FAU - Ovary, Z
AU  - Ovary Z
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens)
RN  - 0 (Dinitrobenzenes)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens/administration & dosage
MH  - Dinitrobenzenes/immunology
MH  - Female
MH  - Immunization, Passive
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunosuppression Therapy
MH  - *Lymphocyte Cooperation
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nippostrongylus/immunology
MH  - Species Specificity
MH  - Spleen/immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC2185649
EDAT- 1979/09/19 00:00
MHDA- 1979/09/19 00:01
PMCR- 1980/03/19
CRDT- 1979/09/19 00:00
PHST- 1979/09/19 00:00 [pubmed]
PHST- 1979/09/19 00:01 [medline]
PHST- 1979/09/19 00:00 [entrez]
PHST- 1980/03/19 00:00 [pmc-release]
AID - 80007920 [pii]
AID - 10.1084/jem.150.3.507 [doi]
PST - ppublish
SO  - J Exp Med. 1979 Sep 19;150(3):507-16. doi: 10.1084/jem.150.3.507.