PMID- 31448702
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 2295-3337 (Electronic)
IS  - 1784-3286 (Linking)
VI  - 76
IP  - 1
DP  - 2021 Feb
TI  - Interplay between metabolic and thyroid parameters in obese pubertal children. 
      Does visceral adipose tissue make the first move?
PG  - 40-48
LID - 10.1080/17843286.2019.1660021 [doi]
AB  - Objectives: The mechanisms of obesity-associated thyroid dysfunction in children 
      are incompletely deciphered. We aimed to evaluate whether visceral adipose tissue 
      (VAT), insulin resistance (IR), inflammation, oxidative stress (OS) are involved 
      in thyroid morpho-functional changes in pubertal obese children. Methods: We 
      recruited 43 obese pubertal children without history of thyroid pathology. 
      Metabolic and thyroid parameters (visceral fat thickness [VFT], waist/hip ratio 
      [WHR], waist/height ratio [WHtR], insulin, glucose, liver parameters, thyroid 
      stimulation hormone [TSH], free thyroxine [FT4], free triiodothyronine [FT3], 
      thyroid and abdominal ultrasonography) were evaluated. Serum monocyte 
      chemoattractant protein-1 (MCP-1) and malondialdehyde (MDA) levels were 
      quantified as markers of inflammation and OS. Results: VFT correlated positively 
      both with WHR (p= 0.034) and the presence of thyroid nodules (p= 0.036). WHR 
      associated with TSH (p= 0.005), FT3/FT4 (p= 0.033) and was independently 
      associated with FT3/FT4 increase (p< 0.001). HOMA-IR increased with visceral 
      obesity (waist circumference, p= 0.001; WHR, p= 0.018; WHtR: p< 0.001), hepatic 
      impairment (alanine aminotransferase, p= 0.019) and hepatic steatosis (HS; 
      p= 0.013) and correlated positively with FT3/FT4 (p= 0.036). TSH was 
      significantly higher in subjects with HS versus those without HS (p= 0.007) and 
      logistic regression analysis identified TSH as a risk factor for HS (p= 0.014). 
      MDA correlated positively with MCP-1 (p= 0.021). Conclusion: VAT and IR may be 
      responsible for changes in thyroid parameters associated with obesity: elevated 
      TSH, FT3/FT4 levels and increased prevalence of thyroid nodules. WHR was 
      predictive of increased FT3/FT4. In obese children, there is an interdependent 
      relationship between HS and thyroid function.
FAU - Racataianu, Nicoleta
AU  - Racataianu N
AD  - Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy 
      , Cluj-Napoca, Romania.
FAU - Leach, Nicoleta V
AU  - Leach NV
AUID- ORCID: 0000-0003-0350-870X
AD  - 5th Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy , Cluj-Napoca, Romania.
FAU - Bolboaca, Sorana D
AU  - Bolboaca SD
AD  - Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University 
      of Medicine and Pharmacy , Cluj-Napoca, Romania.
FAU - Soran, Maria Loredana
AU  - Soran ML
AD  - National Institute for Research and Development of Isotopic and Molecular 
      Technologies , Cluj-Napoca, Romania.
FAU - Opris, Ocsana
AU  - Opris O
AD  - National Institute for Research and Development of Isotopic and Molecular 
      Technologies , Cluj-Napoca, Romania.
FAU - Dronca, Eleonora
AU  - Dronca E
AUID- ORCID: 0000-0002-1829-3070
AD  - Molecular Sciences Department, Iuliu Hatieganu University of Medicine and 
      Pharmacy , Cluj-Napoca, Romania.
FAU - Valea, Ana
AU  - Valea A
AD  - Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy 
      , Cluj-Napoca, Romania.
FAU - Ghervan, Cristina
AU  - Ghervan C
AUID- ORCID: 0000-0003-0016-0349
AD  - Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy 
      , Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190824
PL  - England
TA  - Acta Clin Belg
JT  - Acta clinica Belgica
JID - 0370306
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/analysis
MH  - Child
MH  - Cross-Sectional Studies
MH  - Fatty Liver
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Insulin/analysis
MH  - Insulin Resistance/*physiology
MH  - Intra-Abdominal Fat/*physiopathology
MH  - Male
MH  - *Pediatric Obesity/epidemiology/physiopathology
MH  - Thyroid Diseases
MH  - Thyroid Hormones/*blood
OTO - NOTNLM
OT  - Visceral adiposity
OT  - insulin resistance
OT  - obesity
OT  - systemic inflammation
OT  - thyroid disorders
EDAT- 2019/08/27 06:00
MHDA- 2023/02/25 06:00
CRDT- 2019/08/27 06:00
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2019/08/27 06:00 [entrez]
AID - 10.1080/17843286.2019.1660021 [doi]
PST - ppublish
SO  - Acta Clin Belg. 2021 Feb;76(1):40-48. doi: 10.1080/17843286.2019.1660021. Epub 
      2019 Aug 24.