PMID- 31448816
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200225
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 211
IP  - 8
DP  - 2019 Oct
TI  - Pilot trial of digital breast tomosynthesis (3D mammography) for population-based 
      screening in BreastScreen Victoria.
PG  - 357-362
LID - 10.5694/mja2.50320 [doi]
AB  - OBJECTIVES: To estimate detection measures for tomosynthesis and standard 
      mammography; to assess the feasibility of using tomosynthesis in population-based 
      screening for breast cancer. DESIGN, SETTING: Prospective pilot trial comparing 
      tomosynthesis (with synthesised 2D images) and standard mammography screening of 
      women attending Maroondah BreastScreen, a BreastScreen Victoria service in the 
      eastern suburbs of Melbourne. PARTICIPANTS: Women at least 40 years of age who 
      presented for routine breast screening between 18 August 2017 and 8 November 
      2018. MAIN OUTCOME MEASURES: Cancer detection rate (CDR); proportion of screens 
      that led to recall for further assessment. RESULTS: 5018 tomosynthesis and 5166 
      standard mammography screens were undertaken in 10 146 women; 508 women (5.0% of 
      screens) opted not to undergo tomosynthesis screening. With tomosynthesis, 49 
      cancers (40 invasive, 9 in situ) were detected (CDR, 9.8 [95% CI, 7.2-13] per 
      1000 screens); with standard mammography, 34 cancers (30 invasive, 4 in situ) 
      were detected (CDR, 6.6 [95% CI, 4.6-9.2] per 1000 screens). The estimated 
      difference in CDR was 3.2 more detections (95% CI, -0.32 to 6.8) per 1000 screens 
      with tomosynthesis; the difference was greater for repeat screens and for women 
      aged 60 years or more. The recall rate was greater for tomosynthesis (4.2%; 95% 
      CI, 3.6-4.8%) than standard mammography (3.0%; 95% CI, 2.6-3.5%; estimated 
      difference, 1.2%; 95% CI, 0.46-1.9%). The median screen reading time for 
      tomosynthesis was 67 seconds (interquartile range [IQR] 46-105 seconds); for 
      standard mammography, 16 seconds (IQR, 10-29 seconds). CONCLUSIONS: Breast cancer 
      detection, recall for assessment, and screen reading time were each higher for 
      tomosynthesis than for standard mammography. Our preliminary findings could form 
      the basis of a large scale comparative evaluation of tomosynthesis and standard 
      mammography for breast screening in Australia. TRIAL REGISTRATION: Australian New 
      Zealand Clinical Trials Registry, ACTRN12617000947303.
CI  - (c) 2019 AMPCo Pty Ltd.
FAU - Houssami, Nehmat
AU  - Houssami N
AUID- ORCID: 0000-0002-3641-952X
AD  - Sydney School of Public Health, University of Sydney, Sydney, NSW.
FAU - Lockie, Darren
AU  - Lockie D
AD  - Eastern Health Breast and Cancer Centre, Melbourne, VIC.
FAU - Clemson, Michelle
AU  - Clemson M
AD  - Eastern Health Breast and Cancer Centre, Melbourne, VIC.
FAU - Pridmore, Vicki
AU  - Pridmore V
AD  - BreastScreen Victoria, Melbourne, VIC.
FAU - Taylor, David
AU  - Taylor D
AD  - Box Hill Hospital, Melbourne, VIC.
FAU - Marr, Georgina
AU  - Marr G
AD  - BreastScreen Victoria, Melbourne, VIC.
FAU - Evans, Jill
AU  - Evans J
AD  - BreastScreen Victoria, Melbourne, VIC.
FAU - Macaskill, Petra
AU  - Macaskill P
AD  - Sydney School of Public Health, University of Sydney, Sydney, NSW.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190826
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CIN - Med J Aust. 2019 Oct;211(8):349-350. PMID: 31595509
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast/diagnostic imaging
MH  - Breast Neoplasms/*diagnostic imaging/epidemiology
MH  - *Early Detection of Cancer/methods/statistics & numerical data
MH  - Female
MH  - Humans
MH  - *Mammography
MH  - *Mass Screening/methods/statistics & numerical data
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Victoria
OTO - NOTNLM
OT  - Breast neoplasms
OT  - Mammography
OT  - Mass screening
EDAT- 2019/08/27 06:00
MHDA- 2020/02/26 06:00
CRDT- 2019/08/27 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/06/19 00:00 [accepted]
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/08/27 06:00 [entrez]
AID - 10.5694/mja2.50320 [doi]
PST - ppublish
SO  - Med J Aust. 2019 Oct;211(8):357-362. doi: 10.5694/mja2.50320. Epub 2019 Aug 26.