PMID- 31449444
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20191113
IS  - 1943-5681 (Electronic)
IS  - 0002-9645 (Linking)
VI  - 80
IP  - 9
DP  - 2019 Sep
TI  - Coagulation factor activity in units of leukoreduced and nonleukoreduced canine 
      fresh-frozen plasma.
PG  - 846-851
LID - 10.2460/ajvr.80.9.846 [doi]
AB  - OBJECTIVE: To evaluate coagulation factors in units of leukoreduced (LR) and 
      nonleukoreduced (non-LR) canine fresh-frozen plasma (cFFP). ANIMALS: 8 healthy 
      research dogs. PROCEDURES: In a crossover study, dogs were randomly assigned to 1 
      of 2 groups from which blood was collected and either did or did not undergo 
      leukoreduction. After a recovery period of >/= 28 days, the dogs were switched 
      between protocols. After each collection, blood samples were centrifuged, and 
      cFFP was stored frozen for later comparative analysis of coagulation factors, 
      antithrombin, and protein C activities (reported as comparative percentages of 
      the corresponding activities determined in a canine pooled plasma standard); 
      prothrombin and activated partial thromboplastin times; and fibrinogen 
      concentration. RESULTS: There were no significant differences detected between 
      results for LR cFFP, compared with those for non-LR cFFP. CONCLUSIONS AND 
      CLINICAL RELEVANCE: Although there was variation among residual activities of 
      coagulation factors in LR and non-LR cFFP, the variations and differences were 
      considered unlikely to impact the efficacy of LR cFFP transfused for coagulation 
      factor replacement in dogs. However, owing to the small sample size and high 
      variability of results in the present study, additional research with a larger 
      sample size is required for definitive conclusions on the effects of 
      leukoreduction on coagulation factors in cFFP and to develop treatment guidelines 
      for LR cFFP use in dogs with congenital and acquired coagulopathies.
FAU - Foote, Michelle L
AU  - Foote ML
FAU - Brooks, Marjory B
AU  - Brooks MB
FAU - Archer, Todd M
AU  - Archer TM
FAU - Wills, Robert W
AU  - Wills RW
FAU - Mackin, Andrew J
AU  - Mackin AJ
FAU - Thomason, John M
AU  - Thomason JM
LA  - eng
PT  - Clinical Trial, Veterinary
PT  - Journal Article
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Blood Coagulation Factors)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Animals
MH  - Blood Coagulation Factors/*analysis
MH  - Cross-Over Studies
MH  - Dogs/*blood
MH  - Female
MH  - Fibrinogen/analysis
MH  - Leukocyte Count/veterinary
MH  - *Leukocytes
MH  - Male
MH  - Partial Thromboplastin Time
MH  - Plasma/*chemistry
MH  - Random Allocation
EDAT- 2019/08/27 06:00
MHDA- 2019/11/14 06:00
CRDT- 2019/08/27 06:00
PHST- 2019/08/27 06:00 [entrez]
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
AID - 10.2460/ajvr.80.9.846 [doi]
PST - ppublish
SO  - Am J Vet Res. 2019 Sep;80(9):846-851. doi: 10.2460/ajvr.80.9.846.