PMID- 31449879
OWN - NLM
STAT- MEDLINE
DCOM- 20200519
LR  - 20200519
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 208
DP  - 2019 Nov
TI  - Comparison of serum biomarkers for the diagnosis of macrophage activation 
      syndrome complicating systemic juvenile idiopathic arthritis.
PG  - 108252
LID - S1521-6616(19)30257-8 [pii]
LID - 10.1016/j.clim.2019.108252 [doi]
AB  - Our study aimed to compare the accuracy of serum biomarkers for the diagnosis of 
      macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic 
      arthritis (s-JIA). Serum cytokine levels (neopterin, IL-18, and CXCL9 and soluble 
      tumor necrosis factor receptor type I (sTNFR-I) and II) were determined by 
      enzyme-linked immunosorbent assay in 78 patients with s-JIA, including 21 with 
      MAS. Receiver operating characteristic curve analysis revealed area under the 
      curve values and cut off values of neopterin, IL-18, CXCL9, sTNFR-II/I ratio and 
      ferritin were 0.9465/19.5 nmol/l, 0.8895/69250 ng/ml, 0.9333/3130 pg/ml, 
      0.9395/3.796 and 0.8671/2560 ng/ml, respectively. Serum neopterin levels were 
      significantly elevated in patients with MAS and those were correlated positively 
      with disease activity. In conclusion, serum neopterin levels may be used as a 
      promising indicator of disease activity in s-JIA and MAS and for evaluating it. 
      It may also be a useful marker to diagnose the transition to MAS from 
      active-phase s-JIA.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Takakura, Maiko
AU  - Takakura M
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
FAU - Shimizu, Masaki
AU  - Shimizu M
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan. Electronic address: shimizum@staff.kanazawa-u.ac.jp.
FAU - Irabu, Hitoshi
AU  - Irabu H
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
FAU - Sakumura, Naoto
AU  - Sakumura N
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
FAU - Inoue, Natsumi
AU  - Inoue N
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
FAU - Mizuta, Mao
AU  - Mizuta M
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
FAU - Nakagishi, Yasuo
AU  - Nakagishi Y
AD  - Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children's Hospital, 
      Kobe, Japan.
FAU - Yachie, Akihiro
AU  - Yachie A
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa 
      University, Kanazawa, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190823
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Biomarkers)
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Arthritis, Juvenile/*blood/*complications
MH  - Biomarkers/blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Macrophage Activation Syndrome/*blood/*etiology
MH  - Male
MH  - Neopterin/*blood
OTO - NOTNLM
OT  - Macrophage activation syndrome
OT  - Neopterin
OT  - Systemic juvenile idiopathic arthritis
EDAT- 2019/08/27 06:00
MHDA- 2020/05/20 06:00
CRDT- 2019/08/27 06:00
PHST- 2019/05/16 00:00 [received]
PHST- 2019/08/21 00:00 [revised]
PHST- 2019/08/22 00:00 [accepted]
PHST- 2019/08/27 06:00 [pubmed]
PHST- 2020/05/20 06:00 [medline]
PHST- 2019/08/27 06:00 [entrez]
AID - S1521-6616(19)30257-8 [pii]
AID - 10.1016/j.clim.2019.108252 [doi]
PST - ppublish
SO  - Clin Immunol. 2019 Nov;208:108252. doi: 10.1016/j.clim.2019.108252. Epub 2019 Aug 
      23.