PMID- 31450729
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 55
IP  - 9
DP  - 2019 Aug 23
TI  - Pancreatic Polypeptide-Secreting Tumour of the Proximal Pancreas (PPoma)-Ultra 
      Rare Pancreatic Tumour: Clinically Malign, Histologically Benign.
LID - 10.3390/medicina55090523 [doi]
LID - 523
AB  - Background and objectives: Here we report a rare case of a pancreatic 
      polypeptide-secreting tumour (PPoma) discovered by accident during an autopsy. 
      These PPomas occur in less than 2% of all pancreatic neoplasms and are almost 
      exclusively silent, i.e., they are non-functional. Symptoms arising from PPoma 
      are due to its compression of surrounding tissue. Materials and methods: The 
      autopsy was performed on a 68-year-old male diagnosed with multiple endocrine 
      neoplasm type 1 (MEN1) due to the patient's sudden death. Results: A solitary, 
      densely fibrotic, pink-brown tumour, 18 mm in size tumorous mass, was localised 
      in the head of the pancreas. Microscopically, the tumour had a glandular 
      structure with a tubuloacinar arrangement of the cells. Immunohistochemically, we 
      detected strong PP (pancreatic polypeptide) intracytoplasmic activity and 
      negative glucagon activity. The PPoma was located in the head of the pancreas, 
      likely resulting in the obstruction of the main pancreatic and common bile duct. 
      Conclusions: To the best of our knowledge, this is the first report suggesting 
      the association of PPomas with MEN1. Also, the PPoma could be the cause of acute 
      hemorrhagic pancreatitis due to its location.
FAU - Ilic, Ivan
AU  - Ilic I
AD  - Medical Faculty of Nis, University of Nis, 18000 Nis, Serbia.
FAU - Katic, Vuka
AU  - Katic V
AD  - Policlinic Human, 18000 Nis, Serbia.
FAU - Randjelovic, Pavle
AU  - Randjelovic P
AD  - Medical Faculty of Nis, University of Nis, 18000 Nis, Serbia.
FAU - Stojanovic, Nikola
AU  - Stojanovic N
AUID- ORCID: 0000-0002-0124-3501
AD  - Medical Faculty of Nis, University of Nis, 18000 Nis, Serbia. 
      nikola.st90@yahoo.com.
FAU - Antovic, Aleksandra
AU  - Antovic A
AD  - Medical Faculty of Nis, University of Nis, 18000 Nis, Serbia.
FAU - Ilic, Ratko
AU  - Ilic R
AD  - Medical Faculty of Nis, University of Nis, 18000 Nis, Serbia.
LA  - eng
GR  - 172061/Ministarstvo Prosvete, Nauke i Tehnoloskog Razvoja/
GR  - 175091/Ministarstvo Prosvete, Nauke i Tehnoloskog Razvoja/
PT  - Case Reports
DEP - 20190823
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 59763-91-6 (Pancreatic Polypeptide)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1
MH  - Pancreatic Neoplasms/*diagnosis/genetics/*pathology
MH  - Pancreatic Polypeptide/*analysis
PMC - PMC6780158
OTO - NOTNLM
OT  - PPoma
OT  - neuroendocrine tumours
OT  - pancreatic neoplasms
OT  - pancreatic polypeptide
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/28 06:00
MHDA- 2020/02/25 06:00
PMCR- 2019/08/23
CRDT- 2019/08/28 06:00
PHST- 2019/06/30 00:00 [received]
PHST- 2019/08/13 00:00 [revised]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/08/28 06:00 [entrez]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/08/23 00:00 [pmc-release]
AID - medicina55090523 [pii]
AID - medicina-55-00523 [pii]
AID - 10.3390/medicina55090523 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2019 Aug 23;55(9):523. doi: 10.3390/medicina55090523.