PMID- 31450770
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 9
DP  - 2019 Aug 23
TI  - Brain-Behavior-Immune Interaction: Serum Cytokines and Growth Factors in Patients 
      with Eating Disorders at Extremes of the Body Mass Index (BMI) Spectrum.
LID - 10.3390/nu11091995 [doi]
LID - 1995
AB  - Alterations of the immune system are known in eating disorders (EDs), however the 
      importance of cytokine balance in this context has not been clarified. We 
      compared cytokines and growth factors at opposite ends of BMI ranges, in 90 
      patients classified in relation to BMI, depressive and EDs comorbidities. Serum 
      concentrations of interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, 
      interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and 
      epidermal growth factor (EGF) were determined by a biochip analyzer (Randox 
      Labs). Differences were calculated through ANOVA. Possible predictors of higher 
      cytokine levels were evaluated through regression analysis. IL-1alpha, IL-10, EGF, 
      and IFN-gamma were altered individuals with anorexia nervosa (AN) and binge eating 
      disorder (BED). Night-eating was associated with IL-8 and EGF levels, IL-10 
      concentrations with post-dinner eating and negatively with sweet-eating, long 
      fasting with higher IFN-gamma levels. IL-2 increase was not linked to EDs, but to the 
      interaction of depression and BMI. Altogether, for the first time, IL-1alpha, IL-10, 
      EGF, and IFN-gamma were shown to differ between AN and HCs, and between AN and 
      individuals with obesity with or without BED. Only IL-2 was influenced by 
      depression. Dysfunctional eating behaviors predicted abnormal concentrations of 
      IL-10, EGF, IL-8 and IFN-gamma.
FAU - Caroleo, Mariarita
AU  - Caroleo M
AUID- ORCID: 0000-0001-5856-5344
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Carbone, Elvira Anna
AU  - Carbone EA
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Greco, Marta
AU  - Greco M
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Corigliano, Domenica Maria
AU  - Corigliano DM
AUID- ORCID: 0000-0002-5493-9318
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Arcidiacono, Biagio
AU  - Arcidiacono B
AUID- ORCID: 0000-0003-4343-678X
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Fazia, Gilda
AU  - Fazia G
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Rania, Marianna
AU  - Rania M
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Aloi, Matteo
AU  - Aloi M
AUID- ORCID: 0000-0001-5585-6488
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Gallelli, Luca
AU  - Gallelli L
AUID- ORCID: 0000-0003-0858-7902
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Segura-Garcia, Cristina
AU  - Segura-Garcia C
AUID- ORCID: 0000-0002-5756-3045
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, 88100 Catanzaro, Italy. segura@unicz.it.
FAU - Foti, Daniela Patrizia
AU  - Foti DP
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Brunetti, Antonio
AU  - Brunetti A
AUID- ORCID: 0000-0003-1533-8779
AD  - Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20190823
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anorexia Nervosa/blood/immunology/physiopathology/psychology
MH  - Binge-Eating Disorder/blood/immunology/physiopathology/psychology
MH  - Biomarkers/blood
MH  - *Body Mass Index
MH  - Brain/immunology/*metabolism/physiopathology
MH  - Case-Control Studies
MH  - Cytokines/*blood/immunology
MH  - *Feeding Behavior
MH  - Feeding and Eating Disorders/*blood/immunology/physiopathology/psychology
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Night Eating Syndrome/blood/immunology/physiopathology/psychology
MH  - Time Factors
MH  - *Weight Gain
MH  - *Weight Loss
MH  - Young Adult
PMC - PMC6770139
OTO - NOTNLM
OT  - anorexia nervosa
OT  - binge eating disorder
OT  - cytokines
OT  - eating disorders
OT  - growth factors
OT  - inflammation
OT  - obesity
COIS- The authors report no conflict of interest.
EDAT- 2019/08/28 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/09/01
CRDT- 2019/08/28 06:00
PHST- 2019/07/24 00:00 [received]
PHST- 2019/08/19 00:00 [revised]
PHST- 2019/08/21 00:00 [accepted]
PHST- 2019/08/28 06:00 [entrez]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - nu11091995 [pii]
AID - nutrients-11-01995 [pii]
AID - 10.3390/nu11091995 [doi]
PST - epublish
SO  - Nutrients. 2019 Aug 23;11(9):1995. doi: 10.3390/nu11091995.