PMID- 31451181
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 74
IP  - 11
DP  - 2019 Nov
TI  - Grey matter changes in patients with vestibular migraine.
PG  - 898.e1-898.e5
LID - S0009-9260(19)30359-9 [pii]
LID - 10.1016/j.crad.2019.07.015 [doi]
AB  - AIM: To identify structural changes in the brain regions of patients with 
      vestibular migraine (VM) so as to better understand its pathophysiology. MATERIAL 
      AND METHODS: The differences in grey matter (GM) in patients with VM, patients 
      with migraine without aura (MWoA), and healthy controls (HC) were investigated. 
      Using a GE Signa 3 T magnetic resonance imaging (MRI) system, 3D structural 
      images were acquired from 18 VM, 21 MWoA, and 21 age-, gender-, and education 
      level-matched HC using a T1-weighted magnetization-prepared rapid acquisition 
      gradient-echo (MPRAGE) sequence. The volumetric abnormalities of GM were 
      estimated by voxel-based morphometry. Analysis of variance and Bonferroni 
      multiple comparisons were applied. RESULTS: Compared with HC, patients with VM 
      had significantly increased GM volume of the right medial superior frontal gyrus 
      (p=0.008) and the right angular gyrus (p=0.009). Compared to patients with MWoA, 
      patients with VM also had significantly increased volume of the right medial 
      superior frontal gyrus (p=0.001), the right angular gyrus (p=0.008), and the left 
      middle frontal gyrus (p=0.001). CONCLUSIONS: The GM volume of some brain regions 
      of patients with VM is significantly larger than the other two groups. The 
      increased GM volume in these brain regions in patients with VM may be related to 
      self-adaptation of the nervous system, leading to an abnormal brain 
      sensitization. Some of the brain regions with increased GM volume identified in 
      this study were involved in assessment, integration, and expectations of pain and 
      were strongly related to mood and anxiety.
CI  - Copyright (c) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Wang, S
AU  - Wang S
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
FAU - Wang, H
AU  - Wang H
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China. Electronic address: 1157318363@qq.com.
FAU - Zhao, D
AU  - Zhao D
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
FAU - Liu, X
AU  - Liu X
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
FAU - Yan, W
AU  - Yan W
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
FAU - Wang, M
AU  - Wang M
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
FAU - Zhao, R
AU  - Zhao R
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu 
      Road 16, Qingdao, 266003, China.
LA  - eng
PT  - Journal Article
DEP - 20190823
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Diseases/*pathology
MH  - Female
MH  - Gray Matter/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*pathology
MH  - Vertigo/pathology
MH  - Young Adult
EDAT- 2019/08/28 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/08/28 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/08/28 06:00 [entrez]
AID - S0009-9260(19)30359-9 [pii]
AID - 10.1016/j.crad.2019.07.015 [doi]
PST - ppublish
SO  - Clin Radiol. 2019 Nov;74(11):898.e1-898.e5. doi: 10.1016/j.crad.2019.07.015. Epub 
      2019 Aug 23.