PMID- 31451315
OWN - NLM
STAT- MEDLINE
DCOM- 20201215
LR  - 20201215
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 75
IP  - 2
DP  - 2020 Feb
TI  - Association of body fat mass with left ventricular longitudinal myocardial 
      systolic function in type 2 diabetes mellitus.
PG  - 189-195
LID - S0914-5087(19)30239-4 [pii]
LID - 10.1016/j.jjcc.2019.07.013 [doi]
AB  - BACKGROUND: Left ventricular (LV) longitudinal myocardial systolic dysfunction 
      (LVSD) has been identified in type 2 diabetes mellitus (T2DM) patients, and it 
      should be considered the first marker of a preclinical form of DM-related cardiac 
      dysfunction. Overweight has been postulated to contribute to the development of 
      LVSD in T2DM patients, but the impact of amount of body fat mass on LVSD in T2DM 
      patients remains uncertain. METHODS: We studied 71 asymptomatic T2DM patients 
      with preserved LV ejection fraction (LVEF) (all >/=55%) without coronary artery 
      disease. LVSD for T2DM patients with preserved LVEF was identified as global 
      longitudinal strain (GLS) <18%. Body fat mass was measured with a commercially 
      available body composition analyzer (In Body S-10, Biospace, Tokyo, Japan), and 
      corrected by body surface area (BFI: body fat index). RESULTS: Univariate 
      logistic regression analysis revealed that body weight, body mass index (BMI), 
      and BFI were all associated with LVSD, whereas multivariate logistic regression 
      analysis showed BFI was the only variable independently associated with LVSD (OR 
      1.147; 95% CI 1.001-1.314; p = 0.027). For sequential logistic regression models 
      to predict LVSD, clinical variables including age, DM duration, and HbA1c tended 
      to be improved by addition of BMI, but without statistical significance 
      (p = 0.09), while it was significantly improved by addition of BFI (p = 0.047). 
      CONCLUSIONS: Using BFI for the control of body compression by means of a 
      bioelectrical impedance assay is simple and easy-to-use, and this may have 
      clinical implications for better management of T2DM patients with preserved LVEF 
      to prevent future development of DM-related cardiac dysfunction.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Hatani, Yutaka
AU  - Hatani Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Tanaka, Hidekazu
AU  - Tanaka H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan. Electronic address: 
      tanakah@med.kobe-u.ac.jp.
FAU - Mochizuki, Yasuhide
AU  - Mochizuki Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Suto, Makiko
AU  - Suto M
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Yokota, Shun
AU  - Yokota S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Mukai, Jun
AU  - Mukai J
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Takada, Hiroki
AU  - Takada H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Soga, Fumitaka
AU  - Soga F
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Hatazawa, Keiko
AU  - Hatazawa K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Matsuzoe, Hiroki
AU  - Matsuzoe H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Matsumoto, Kensuke
AU  - Matsumoto K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Hirota, Yushi
AU  - Hirota Y
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Ogawa, Wataru
AU  - Ogawa W
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Hirata, Ken-Ichi
AU  - Hirata KI
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190824
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - *Adipose Tissue
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Systole
MH  - Ventricular Dysfunction, Left/etiology/*physiopathology
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Body fat
OT  - Diabetes mellitus
OT  - Left ventricular diastolic function
OT  - Left ventricular longitudinal function
EDAT- 2019/08/28 06:00
MHDA- 2020/12/16 06:00
CRDT- 2019/08/28 06:00
PHST- 2019/04/05 00:00 [received]
PHST- 2019/07/08 00:00 [revised]
PHST- 2019/07/11 00:00 [accepted]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2020/12/16 06:00 [medline]
PHST- 2019/08/28 06:00 [entrez]
AID - S0914-5087(19)30239-4 [pii]
AID - 10.1016/j.jjcc.2019.07.013 [doi]
PST - ppublish
SO  - J Cardiol. 2020 Feb;75(2):189-195. doi: 10.1016/j.jjcc.2019.07.013. Epub 2019 Aug 
      24.