PMID- 31451414
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20210908
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 44
IP  - 3
DP  - 2020 Jun
TI  - Quantative HBsAg level correlates dendritic cells maturation in chronic hepatitis 
      B patients.
PG  - 321-328
LID - S2210-7401(19)30182-2 [pii]
LID - 10.1016/j.clinre.2019.07.016 [doi]
AB  - BACKGROUND: In order to better understand the role of Dendritic cells (DCs) in 
      Chronic Hepatitis B (CHB), we investigated the frequencies and maturation markers 
      on DCs in CHB patients and its change during entecavir treatment. METHODS: 
      Twenty-six CHB patients on anti-virus treatment for 48 weeks were included in 
      this study. Patients' blood samples were collected on every 3 months since 
      starting treatment. Samples on baseline and after 48 weeks treatment were 
      examined using flow-cytometry to investigate frequencies and maturation markers 
      of DCs. RESULTS: The frequencies of myeloid DCs (mDCs) and plasmacytoid DCs 
      (pDCs) were lower in CHB patients than healthy controls on baseline. pDCs 
      frequencies and mDCs maturation markers expression were increased after entecavir 
      (ETV) treatment. Patients with higher baseline HBsAg levels showed a poorer 
      maturation status than those with low baseline HBsAg levels, regardless of 
      changes in HBsAg levels after treatment. CONCLUSIONS: Entecavir treatment could 
      restore the decreased DCs frequencies in CHB patients and improve DCs maturation 
      levels. Baseline HBsAg level is an important factor that affecting DCs.
CI  - Copyright (c) 2019 Elsevier Masson SAS. All rights reserved.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Department of Critical Care Medicine, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Gu, Yurong
AU  - Gu Y
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Lubiao
AU  - Chen L
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Gu, Lin
AU  - Gu L
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Huang, Yuehua
AU  - Huang Y
AD  - Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Liver 
      Research, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 
      China. Electronic address: huangyh53@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190823
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
RN  - 0 (Antiviral Agents)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 5968Y6H45M (entecavir)
RN  - 5Z93L87A1R (Guanine)
SB  - IM
MH  - Adult
MH  - Antiviral Agents/therapeutic use
MH  - *Cell Differentiation/drug effects
MH  - Dendritic Cells/*cytology/drug effects
MH  - Female
MH  - Flow Cytometry
MH  - Guanine/analogs & derivatives/therapeutic use
MH  - Hepatitis B Surface Antigens/*blood
MH  - Hepatitis B, Chronic/*blood/drug therapy
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Chronic Hepatitis B
OT  - Dendritic Cells
OT  - HBsAg
EDAT- 2019/08/28 06:00
MHDA- 2021/09/09 06:00
CRDT- 2019/08/28 06:00
PHST- 2019/04/03 00:00 [received]
PHST- 2019/06/16 00:00 [revised]
PHST- 2019/07/18 00:00 [accepted]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
PHST- 2019/08/28 06:00 [entrez]
AID - S2210-7401(19)30182-2 [pii]
AID - 10.1016/j.clinre.2019.07.016 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2020 Jun;44(3):321-328. doi: 
      10.1016/j.clinre.2019.07.016. Epub 2019 Aug 23.