PMID- 31453348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 4
IP  - 4
DP  - 2019 Aug
TI  - PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal 
      Cancer Treated With Radiotherapy.
PG  - 399-404
LID - 10.1002/lio2.272 [doi]
AB  - OBJECTIVES: The aim of this study was to establish the prognostic value of the 
      epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog 
      deleted on chromosome 10 (PTEN) expression on local control in patients with 
      early stage supraglottic laryngeal squamous cell carcinoma (LSCC) treated with 
      radiotherapy only. STUDY DESIGN: Retrospective cohort study. METHODS: 
      Immunohistochemical staining for EGFR and PTEN was performed on pretreatment 
      biopsies of a selected well-defined homogeneous group of 52 patients with T1-T2 
      supraglottic LSCC treated with radiotherapy between 1990 and 2008. Kaplan-Meier 
      analysis and univariate and multivariate Cox Regression analyses were performed 
      to correlate clinical data and expression levels of EGFR and PTEN with local 
      control. RESULTS: Kaplan-Meier survival analysis and Cox Regression analysis 
      showed a significant association between PTEN expression and local control 
      (hazard ratio [HR] = 3.26, 95% confidence interval [CI] = 1.14-9.33, P = .027) 
      and between lymph node status and local control (HR = 3.60, 95% CI = 1.26-10.31, 
      P = .017). Both were independent prognostic factors in a multivariate analysis 
      (HR = 3.28, 95% CI = 1.14-9.39, P = .027 and HR = 3.62, 95% CI = 1.26-10.37, P = 
      .017, respectively). There was no significant association between EGFR expression 
      and local control (HR = 1.32, 95% CI = 1.17-10.14, P = .79). CONCLUSION: This 
      study showed an association between both high PTEN expression and the presence of 
      lymph node metastasis and deteriorated local control in early stage supraglottic 
      LSCC treated with radiotherapy. LEVEL OF EVIDENCE: NA.
FAU - Bruine de Bruin, Leonie
AU  - Bruine de Bruin L
AUID- ORCID: 0000-0003-1240-9236
AD  - Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center 
      Groningen, University of Groningen Groningen The Netherlands.
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
FAU - Wachters, Jan E
AU  - Wachters JE
AD  - Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center 
      Groningen, University of Groningen Groningen The Netherlands.
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
FAU - Schrijvers, Michiel L
AU  - Schrijvers ML
AD  - Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center 
      Groningen, University of Groningen Groningen The Netherlands.
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
FAU - Slagter-Menkema, Lorian
AU  - Slagter-Menkema L
AD  - Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center 
      Groningen, University of Groningen Groningen The Netherlands.
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
AD  - Department of Pathology and Medical Biology University Medical Center Groningen, 
      University of Groningen Groningen The Netherlands.
FAU - Mastik, Mirjam F
AU  - Mastik MF
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
AD  - Department of Pathology and Medical Biology University Medical Center Groningen, 
      University of Groningen Groningen The Netherlands.
FAU - Langendijk, Johannes A
AU  - Langendijk JA
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
AD  - Department of Radiation Oncology University Medical Center Groningen, University 
      of Groningen Groningen The Netherlands.
FAU - van der Wal, Jacqueline E
AU  - van der Wal JE
AD  - Department of Pathology and Medical Biology University Medical Center Groningen, 
      University of Groningen Groningen The Netherlands.
FAU - Schuuring, Ed
AU  - Schuuring E
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
AD  - Department of Pathology and Medical Biology University Medical Center Groningen, 
      University of Groningen Groningen The Netherlands.
FAU - van der Laan, Bernard F A M
AU  - van der Laan BFAM
AD  - Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center 
      Groningen, University of Groningen Groningen The Netherlands.
AD  - Graduate School of Medical Sciences (Groningen University Institute for Drug 
      Exploration) University of Groningen Groningen The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20190612
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC6703112
OTO - NOTNLM
OT  - EGFR
OT  - PTEN
OT  - laryngeal squamous cell carcinoma
OT  - local control
OT  - radiotherapy
EDAT- 2019/08/28 06:00
MHDA- 2019/08/28 06:01
PMCR- 2019/06/12
CRDT- 2019/08/28 06:00
PHST- 2019/03/04 00:00 [received]
PHST- 2019/04/08 00:00 [revised]
PHST- 2019/04/16 00:00 [accepted]
PHST- 2019/08/28 06:00 [entrez]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2019/08/28 06:01 [medline]
PHST- 2019/06/12 00:00 [pmc-release]
AID - LIO2272 [pii]
AID - 10.1002/lio2.272 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2019 Jun 12;4(4):399-404. doi: 
      10.1002/lio2.272. eCollection 2019 Aug.