PMID- 31453785
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20201006
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 16
IP  - 12
DP  - 2019
TI  - Strong Association of Serum GSK-3beta/BDNF Ratio with Mild Cognitive Impairment in 
      Elderly Type 2 Diabetic Patients.
PG  - 1151-1160
LID - 10.2174/1567205016666190827112546 [doi]
AB  - BACKGROUND: Glycogen Synthase Kinase (GSK)-3beta and Brain-derived Neurotrophic 
      Factor (BDNF) play vital roles in both Mild Cognitive Impairment (MCI) and Type 2 
      Diabetes Mellitus (T2DM). The underlying mechanisms may involve inflammation and 
      oxidative stress. OBJECTIVES: To investigate the association of the GSK-3beta/BDNF 
      ratio with MCI in elderly patients with T2DM and whether GSK-3beta/BDNF ratio can 
      serve as a new diagnostic biomarker for MCI in comorbid with T2DM (MD). METHODS: 
      A total of 326 old Chinese T2DM patients were included and stratified according 
      to cognition and GSK-3beta/BDNF ratio quartiles. MCI was diagnosed according to the 
      National Institute on Aging Alzheimer's Association workgroups criteria. In 
      addition to routine hematuria and biochemical examinations, Montreal Cognitive 
      Assessment (MoCA) scale was also used to evaluate the cognitive function, and 
      ELISA method was used to measure GSK-3beta activity and the serum levels of BDNF, 
      interleukin 1beta (IL-1beta), high mobility group box-1 (HMGB1) protein, Malonaldehyde 
      (MDA) and 8-isoprostaglandinF2alpha (8-iso-PGF2alpha). RESULTS: We found that GSK-3beta 
      activity was negatively correlated with BDNF (r=-0.270, P=0.008), and patients 
      with higher GSK-3beta/BDNF ratio had lower MoCA scores (P=0.001). When compared with 
      T2DM patients without MCI (nMD), MD patients had higher GSK-3beta activity and 
      GSK-3beta/BDNF ratio, but lower BDNF levels. As for inflammation and oxidative 
      stress, IL-1beta was inversely correlated with GSK-3beta activity, while 8-isoPGF2alpha was 
      positively correlated with GSK-3beta activity and GSK-3beta/BDNF ratio. The odds ratio 
      for MCI increased gradually when GSK-3beta/BDNF ratio quartile rose from the lowest 
      to the highest (6.90, 95% CI 3.22-14.78). MoCA score was conversely related to 
      GSK-3beta/BDNF ratio, age and fast blood glucose (FBG), with GSK-3beta/BDNF ratio 
      having the most significant influence on cognition (beta=-0.199, P<0.001). 
      CONCLUSION: Our data provide evidence for a strong link between GSK-3beta/BDNF ratio 
      and MCI. GSK- 3beta/BDNF ratio may serve as a better diagnostic biomarker for MD 
      than either GSK-3beta or BDNF alone and increased GSK-3beta/BDNF ratio indicates a 
      worse cognitive function.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Du, Bingying
AU  - Du B
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
FAU - Lian, Yongjie
AU  - Lian Y
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
FAU - Chen, Chao
AU  - Chen C
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
FAU - Zhang, Hailing
AU  - Zhang H
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
FAU - Bi, Yueping
AU  - Bi Y
AD  - Yinhang Community Health Service Center of Yangpu District, Shanghai 200433, 
      China.
FAU - Fan, Cunxiu
AU  - Fan C
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
FAU - Bi, Xiaoying
AU  - Bi X
AD  - Department of Neurology, Shanghai Changhai Hospital, Navy Medical University, 
      Shanghai 200433, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognitive Dysfunction/*blood/*epidemiology/psychology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology/psychology
MH  - Female
MH  - Glycogen Synthase Kinase 3 beta/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
OTO - NOTNLM
OT  - Mild cognitive impairment
OT  - brain-derived neurotrophic factor
OT  - glycogen synthase kinase-3beta
OT  - inflammation
OT  - oxidative stress
OT  - type 2 diabetes.
EDAT- 2019/08/28 06:00
MHDA- 2020/10/07 06:00
CRDT- 2019/08/28 06:00
PHST- 2019/03/12 00:00 [received]
PHST- 2019/08/07 00:00 [revised]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/08/28 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2019/08/28 06:00 [entrez]
AID - CAR-EPUB-100462 [pii]
AID - 10.2174/1567205016666190827112546 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2019;16(12):1151-1160. doi: 
      10.2174/1567205016666190827112546.