PMID- 31454971
OWN - NLM
STAT- MEDLINE
DCOM- 20200121
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 17
DP  - 2019 Aug 26
TI  - Anti-Inflammatory Effects of Phenolic Compounds Isolated from Quercus Mongolica 
      Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells.
LID - 10.3390/molecules24173094 [doi]
LID - 3094
AB  - Quercus mongolica Fisch. ex Ledeb. (QM) has been used as an oriental traditional 
      medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory 
      activities of the extracts and compounds (1-6) isolated from QM on the production 
      of inflammatory cytokines and chemokines to evaluate their anti-inflammatory 
      activities. Further, we evaluated the expression levels of cytokines, chemokines, 
      and immune factors on pedunculagin (PC, 1), which was selected from isolated 
      compounds (1-6) because of its potential anti-inflammation effect. Additionally, 
      we evaluated whether the inflammation mitigation effects of PC (1) following UVB 
      exposure in keratinocytes occurred because of nuclear factor (NF)-kappaB and signal 
      transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. 
      PC (1) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte 
      chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression 
      level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 
      mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and 
      extracellular signal-regulated kinase (ERK) in a concentration-dependent manner.
FAU - Yin, Jun
AU  - Yin J
AD  - Department of Pharmacognosy and Natural product-derived Medicine, College of 
      Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
FAU - Kim, Han Hyuk
AU  - Kim HH
AD  - Department of Pharmacognosy and Natural product-derived Medicine, College of 
      Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
FAU - Hwang, In Hyeok
AU  - Hwang IH
AD  - Department of Pharmacognosy and Natural product-derived Medicine, College of 
      Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
FAU - Kim, Dong Hee
AU  - Kim DH
AD  - R&D Department Applied Product Development Team, Traditional Korean Medicine 
      Technology Division, 94, Hwarang-ro(Gapje-dong), Gyeongsan-si, Gyeongsangbuk-do 
      38540, Korea.
FAU - Lee, Min Won
AU  - Lee MW
AD  - Department of Pharmacognosy and Natural product-derived Medicine, College of 
      Pharmacy, Chung-Ang University, Seoul 156-756, Korea. mwlee@cau.ac.kr.
LA  - eng
GR  - Project No. 2017037B10-1819-BA01/Korea Forest Service/
PT  - Journal Article
DEP - 20190826
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Tannins)
RN  - 1KN18B7Y0X (pedunculagin)
SB  - IM
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Cytokines/genetics/metabolism
MH  - Drug Evaluation, Preclinical
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Keratinocytes/*cytology/drug effects/radiation effects
MH  - Lipopolysaccharides/adverse effects
MH  - NF-kappa B
MH  - Phenols/chemistry/*pharmacology
MH  - Phosphorylation
MH  - Plant Extracts/chemistry/pharmacology
MH  - Quercus/*chemistry
MH  - Signal Transduction/drug effects
MH  - Tannins/chemistry/*pharmacology
MH  - Ultraviolet Rays/adverse effects
PMC - PMC6749265
OTO - NOTNLM
OT  - Quercus mongolica Fisch. ex Ledeb.
OT  - pedunculagin
OT  - skin inflammation disease
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2019/08/29 06:00
MHDA- 2020/01/22 06:00
PMCR- 2019/08/26
CRDT- 2019/08/29 06:00
PHST- 2019/08/09 00:00 [received]
PHST- 2019/08/23 00:00 [revised]
PHST- 2019/08/23 00:00 [accepted]
PHST- 2019/08/29 06:00 [entrez]
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2020/01/22 06:00 [medline]
PHST- 2019/08/26 00:00 [pmc-release]
AID - molecules24173094 [pii]
AID - molecules-24-03094 [pii]
AID - 10.3390/molecules24173094 [doi]
PST - epublish
SO  - Molecules. 2019 Aug 26;24(17):3094. doi: 10.3390/molecules24173094.