PMID- 31455291
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20231013
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Aug 27
TI  - Severity of depression, anxious distress and the risk of type 2 diabetes - a 
      population-based cohort study in Sweden.
PG  - 1174
LID - 10.1186/s12889-019-7322-z [doi]
LID - 1174
AB  - BACKGROUND: Previous studies assessing the relationship between depression and 
      diabetes mellitus did not consider the severity of depression. In the present 
      study we assessed the risk of developing type 2 diabetes mellitus (T2DM) among 
      people with various severity of depression. METHODS: This prospective 
      longitudinal cohort study included 9,936 individuals residing in Stockholm 
      County, Sweden who responded to the baseline questionnaire in 1998-2000. The 
      participants were followed from 1 year after the baseline up to 2015 for the 
      occurrence of T2DM, using the National Patient Register, Swedish Prescribed Drug 
      Registers, and Cause of Death Register. Depression and anxious distress were 
      assessed using psychiatric rating scales and defined according to the Diagnostic 
      and Statistical Manual of Mental Disorders (DSM-5). RESULTS: Depression was 
      associated with a statistically significant increased risk of T2DM after 
      adjusting for potential confounders (OR 1.48, CI 1.10, 1.99). The strongest 
      association was observed for severe depression (OR 1.72, CI 1.15, 2.59). Further, 
      those with depression, regardless of severity, and with concurrent 
      moderate/severe anxious distress had an increased risk of T2DM (OR 1.73, CI 1.13, 
      2.63) compared to those with neither depression nor anxious distress. 
      CONCLUSIONS: The study adds evidence that depression is associated with a higher 
      risk for developing T2DM, and the association is stronger among people with 
      severe depression.
FAU - Deleskog, Anna
AU  - Deleskog A
AUID- ORCID: 0000-0003-3842-6982
AD  - Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institutet, 
      SE 171 77, Stockholm, Sweden. deleskog.anna@gmail.com.
FAU - Ljung, Rickard
AU  - Ljung R
AD  - Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institutet, 
      SE 171 77, Stockholm, Sweden.
FAU - Forsell, Yvonne
AU  - Forsell Y
AD  - Department of Public Health Sciences, Karolinska Institutet, SE 171 77, 
      Stockholm, Sweden.
FAU - Nevriana, Alicia
AU  - Nevriana A
AD  - Department of Public Health Sciences, Karolinska Institutet, SE 171 77, 
      Stockholm, Sweden.
FAU - Almas, Aysha
AU  - Almas A
AD  - Department of Public Health Sciences, Karolinska Institutet, SE 171 77, 
      Stockholm, Sweden.
AD  - Department of Medicine, Aga Khan University, Karachi, Pakistan.
FAU - Moller, Jette
AU  - Moller J
AD  - Department of Public Health Sciences, Karolinska Institutet, SE 171 77, 
      Stockholm, Sweden.
LA  - eng
GR  - NA/Stockholms Lans Landsting/
GR  - NA/Svenska Forskningsradet Formas/
PT  - Journal Article
DEP - 20190827
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
EIN - BMC Public Health. 2019 Sep 13;19(1):1268. PMID: 31519164
MH  - Adult
MH  - Aged
MH  - Anxiety/*epidemiology
MH  - Cohort Studies
MH  - Depression/*epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - *Severity of Illness Index
MH  - Sweden/epidemiology
PMC - PMC6712830
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - Longitudinal data
OT  - Type 2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2019/08/29 06:00
MHDA- 2019/11/27 06:00
PMCR- 2019/08/27
CRDT- 2019/08/29 06:00
PHST- 2019/03/22 00:00 [received]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/29 06:00 [entrez]
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2019/08/27 00:00 [pmc-release]
AID - 10.1186/s12889-019-7322-z [pii]
AID - 7322 [pii]
AID - 10.1186/s12889-019-7322-z [doi]
PST - epublish
SO  - BMC Public Health. 2019 Aug 27;19(1):1174. doi: 10.1186/s12889-019-7322-z.