PMID- 31455687
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 42
IP  - 11
DP  - 2019 Nov
TI  - High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid 
      Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic 
      Chinese Adults.
PG  - 2117-2126
LID - 10.2337/dc19-0100 [doi]
AB  - OBJECTIVE: Comprehensive assessment of serum lipidomic aberrations before type 2 
      diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated 
      changes in lipid coregulation antecedent to T2DM and identified novel lipid 
      predictors for T2DM in individuals with normal glucose regulation (NGR). RESEARCH 
      DESIGN AND METHODS: In the discovery study, we tested 667 baseline serum lipids 
      in subjects with incident diabetes and propensity score-matched control subjects 
      (n = 200) from a prospective cohort comprising 3,821 Chinese adults with NGR. In 
      the validation study, we tested 250 lipids in subjects with incident diabetes and 
      matched control subjects (n = 724) from a pooled validation cohort of 14,651 
      individuals with NGR covering five geographical regions across China. 
      Differential correlation network analyses revealed perturbed lipid coregulation 
      antecedent to diabetes. The predictive value of a serum lipid panel independent 
      of serum triglycerides and 2-h postload glucose was also evaluated. RESULTS: At 
      the level of false-discovery rate <0.05, 38 lipids, including triacylglycerols 
      (TAGs), lyso-phosphatidylinositols, phosphatidylcholines, polyunsaturated fatty 
      acid (PUFA)-plasmalogen phosphatidylethanolamines (PUFA-PEps), and cholesteryl 
      esters, were significantly associated with T2DM risk in the discovery and 
      validation cohorts. A preliminary study found most of the lipid predictors were 
      also significantly associated with the risk of prediabetes. Differential 
      correlation network analysis revealed that perturbations in intraclass (i.e., 
      non-PUFA-TAG and PUFA-TAGs) and interclass (i.e., TAGs and PUFA-PEps) lipid 
      coregulation preexisted before diabetes onset. Our lipid panel further improved 
      prediction of incident diabetes over conventional clinical indices. CONCLUSIONS: 
      These findings revealed novel changes in lipid coregulation existing before 
      diabetes onset and expanded the current panel of serum lipid predictors for T2DM 
      in normoglycemic Chinese individuals.
CI  - (c) 2019 by the American Diabetes Association.
FAU - Lu, Jieli
AU  - Lu J
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Lam, Sin Man
AU  - Lam SM
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Affiliated Hospital of Southwest Medical University, Luzhou, China.
FAU - Shi, Lixin
AU  - Shi L
AD  - Affiliated Hospital of Guiyang Medical College, Guiyang, China.
FAU - Huo, Yanan
AU  - Huo Y
AD  - Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, 
      China.
FAU - Chen, Lulu
AU  - Chen L
AUID- ORCID: 0000-0001-9621-9231
AD  - Union Hospital, Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, China.
FAU - Tang, Xulei
AU  - Tang X
AD  - The First Hospital of Lanzhou University, Lanzhou, China.
FAU - Li, Bowen
AU  - Li B
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Wu, Xueyan
AU  - Wu X
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Peng, Kui
AU  - Peng K
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Li, Mian
AU  - Li M
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Wang, Shuangyuan
AU  - Wang S
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Xu, Yu
AU  - Xu Y
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Xu, Min
AU  - Xu M
AUID- ORCID: 0000-0003-4464-453X
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Bi, Yufang
AU  - Bi Y
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Ning, Guang
AU  - Ning G
AUID- ORCID: 0000-0002-5754-7635
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China.
FAU - Shui, Guanghou
AU  - Shui G
AUID- ORCID: 0000-0002-1621-9643
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, Beijing, China 
      wqingw61@163.com ghshui@genetics.ac.cn.
FAU - Wang, Weiqing
AU  - Wang W
AUID- ORCID: 0000-0001-6027-3084
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commision of the People's Republic of China, Shanghai Institute of Endocrine and 
      Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of 
      Medicine, Shanghai, China wqingw61@163.com ghshui@genetics.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190827
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Asian People/statistics & numerical data
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/ethnology
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Lipidomics/*methods
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood/ethnology
MH  - Predictive Value of Tests
MH  - Propensity Score
MH  - Prospective Studies
MH  - Risk Assessment/methods
MH  - Triglycerides/blood
EDAT- 2019/08/29 06:00
MHDA- 2020/07/09 06:00
CRDT- 2019/08/29 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2019/08/29 06:00 [entrez]
AID - dc19-0100 [pii]
AID - 10.2337/dc19-0100 [doi]
PST - ppublish
SO  - Diabetes Care. 2019 Nov;42(11):2117-2126. doi: 10.2337/dc19-0100. Epub 2019 Aug 
      27.