PMID- 31455883
OWN - NLM
STAT- MEDLINE
DCOM- 20201029
LR  - 20231013
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Aug 27
TI  - Interference-free Detection of Lipid-laden Atherosclerotic Plaques by 3D 
      Co-registration of Frequency-Domain Differential Photoacoustic and Ultrasound 
      Radar Imaging.
PG  - 12400
LID - 10.1038/s41598-019-48896-6 [doi]
LID - 12400
AB  - As lipid composition of atherosclerotic plaques is considered to be one of the 
      primary indicators for plaque vulnerability, a diagnostic modality that can 
      sensitively evaluate their necrotic core is highly desirable in atherosclerosis 
      imaging. In this regard, intravascular photoacoustic (IVPA) imaging is an 
      emerging plaque detection modality that provides lipid-specific chemical 
      information of arterial walls. Within the near-infrared window, a 1210-nm optical 
      source is usually chosen for IVPA applications because lipid exhibits a strong 
      absorption peak at that wavelength. However, other arterial tissues also show 
      some degree of absorption near 1210 nm and generate undesirable interfering PA 
      signals. In this study, a novel wavelength-modulated Intravascular Differential 
      Photoacoustic Radar (IV-DPAR) modality was introduced as an interference-free 
      detection technique for a more accurate and reliable diagnosis of plaque 
      progression. By using two low-power continuous-wave laser diodes in a 
      differential manner, IV-DPAR could efficiently suppress undesirable absorptions 
      and system noise, while dramatically improving system sensitivity and specificity 
      to cholesterol, the primary ingredient of plaque necrotic core. When 
      co-registered with intravascular ultrasound imaging, IV-DPAR could sensitively 
      locate and characterize the lipid contents of plaques in human atherosclerotic 
      arteries, regardless of their size and depth.
FAU - Choi, Sung Soo Sean
AU  - Choi SSS
AUID- ORCID: 0000-0002-5512-6335
AD  - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), 
      University of Toronto, Toronto, ON, M5S3G8, Canada.
FAU - Lashkari, Bahman
AU  - Lashkari B
AD  - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), 
      University of Toronto, Toronto, ON, M5S3G8, Canada.
FAU - Mandelis, Andreas
AU  - Mandelis A
AD  - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), 
      University of Toronto, Toronto, ON, M5S3G8, Canada. mandelis@mie.utoronto.ca.
FAU - Weyers, Jill J
AU  - Weyers JJ
AUID- ORCID: 0000-0003-2358-1162
AD  - Physical Sciences Department, Sunnybrook Research Institute, Toronto, ON, M4N3M5, 
      Canada.
FAU - Boyes, Aaron
AU  - Boyes A
AD  - Physical Sciences Department, Sunnybrook Research Institute, Toronto, ON, M4N3M5, 
      Canada.
FAU - Foster, Stuart F
AU  - Foster SF
AD  - Physical Sciences Department, Sunnybrook Research Institute, Toronto, ON, M4N3M5, 
      Canada.
FAU - Alves-Kotzev, Natasha
AU  - Alves-Kotzev N
AD  - Conavi Medical Inc., North York, ON, M3B2V1, Canada.
FAU - Courtney, Brian
AU  - Courtney B
AD  - Physical Sciences Department, Sunnybrook Research Institute, Toronto, ON, M4N3M5, 
      Canada.
AD  - Conavi Medical Inc., North York, ON, M3B2V1, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190827
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Lipids)
SB  - IM
MH  - Arteries/diagnostic imaging
MH  - Atherosclerosis/diagnosis/*diagnostic imaging
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Lipids/*chemistry
MH  - Photoacoustic Techniques/*methods
MH  - Ultrasonography, Interventional/*methods
PMC - PMC6712001
COIS- The authors declare no competing interests.
EDAT- 2019/08/29 06:00
MHDA- 2020/10/30 06:00
PMCR- 2019/08/27
CRDT- 2019/08/29 06:00
PHST- 2019/03/14 00:00 [received]
PHST- 2019/08/15 00:00 [accepted]
PHST- 2019/08/29 06:00 [entrez]
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2020/10/30 06:00 [medline]
PHST- 2019/08/27 00:00 [pmc-release]
AID - 10.1038/s41598-019-48896-6 [pii]
AID - 48896 [pii]
AID - 10.1038/s41598-019-48896-6 [doi]
PST - epublish
SO  - Sci Rep. 2019 Aug 27;9(1):12400. doi: 10.1038/s41598-019-48896-6.