PMID- 31460577
OWN - NLM
STAT- MEDLINE
DCOM- 20190905
LR  - 20190906
IS  - 1678-4219 (Electronic)
IS  - 0004-2803 (Linking)
VI  - 56
IP  - 2
DP  - 2019 Aug 13
TI  - HLA-DRB1 GENE POLYMORPHISMS IN PEDIATRIC PATIENTS WITH TYPE 1 AUTOIMMUNE 
      HEPATITIS AND TYPE 1 AUTOIMMUNE HEPATITIS OVERLAP SYNDROME WITH AUTOIMMUNE 
      CHOLANGITIS.
PG  - 146-150
LID - S0004-28032019000200146 [pii]
LID - 10.1590/S0004-2803.201900000-29 [doi]
AB  - BACKGROUND: Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver 
      disease associated with a loss of immunological tolerance to self-antigens. 
      Susceptibility to AIH is partially determined by the presence of genes related to 
      human leukocyte antigen (HLA), mainly allelic variants of DRB1. OBJECTIVE: The 
      purpose of this study was to investigate the frequencies of the polymorphisms in 
      HLA-DRB1 gene in children and adolescents with type 1 AIH and type 1 AIH overlap 
      syndrome with autoimmune cholangitis (overlap syndrome, OS) in comparison to 
      healthy sex and age-matched individuals (control group). METHODS: This is a 
      cross-sectional study of 25 pediatric patients diagnosed with type 1 AIH and 18 
      with OS. Fifty-seven healthy individuals were included as controls. The 
      polymorphisms of the HLA-DRB1 gene were evaluated by PCR and included 
      HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*07, and HLA-DRB1*13. RESULTS: Our results 
      showed that the presence of the allele HLA-DRB1*13 increased the chance of 
      autoimmune cholangitis (OR=3.96, CI 1.07 to 14.61, P=0.04). The HLA-DRB1*04 and 
      HLA- DRB1*07 have no association with the AIH and autoimmune cholangitis in a 
      young sample. CONCLUSION: This work demonstrates an association of the main 
      polymorphisms in the HLA-DRB1 gene to AIH with or without cholangitis in a 
      Brazilian sample.
FAU - Nunes, Monique Ellen Gervasio
AU  - Nunes MEG
AUID- ORCID: 0000-0002-4291-9221
AD  - Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratorio de 
      Medicina Molecular, Belo Horizonte, MG, Brasil.
FAU - Rosa, Daniela Valadao
AU  - Rosa DV
AUID- ORCID: 0000-0001-8868-7895
AD  - Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratorio de 
      Medicina Molecular, Belo Horizonte, MG, Brasil.
FAU - Fagundes, Eleonora Druve Tavares
AU  - Fagundes EDT
AUID- ORCID: 0000-0002-5671-9570
AD  - Universidade Federal de Minas Gerais, Hospital das Clinicas, Servico de 
      Gastroenterologia Pediatrica, Belo Horizonte, MG, Brasil.
FAU - Ferreira, Alexandre Rodrigues
AU  - Ferreira AR
AUID- ORCID: 0000-0001-6749-8980
AD  - Universidade Federal de Minas Gerais, Hospital das Clinicas, Servico de 
      Gastroenterologia Pediatrica, Belo Horizonte, MG, Brasil.
FAU - Miranda, Debora Marques de
AU  - Miranda DM
AUID- ORCID: 0000-0002-7081-8401
AD  - Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratorio de 
      Medicina Molecular, Belo Horizonte, MG, Brasil.
FAU - Ferri Liu, Priscila Menezes
AU  - Ferri Liu PM
AUID- ORCID: 0000-0002-8608-8503
AD  - Universidade Federal de Minas Gerais, Hospital das Clinicas, Servico de 
      Gastroenterologia Pediatrica, Belo Horizonte, MG, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20190813
PL  - Brazil
TA  - Arq Gastroenterol
JT  - Arquivos de gastroenterologia
JID - 15310600R
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Cholangitis/*genetics
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Hepatitis, Autoimmune/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Undifferentiated Connective Tissue Diseases/*genetics
MH  - Young Adult
EDAT- 2019/08/29 06:00
MHDA- 2019/09/07 06:00
CRDT- 2019/08/29 06:00
PHST- 2019/01/08 00:00 [received]
PHST- 2019/03/19 00:00 [accepted]
PHST- 2019/08/29 06:00 [entrez]
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
AID - S0004-28032019000200146 [pii]
AID - 10.1590/S0004-2803.201900000-29 [doi]
PST - epublish
SO  - Arq Gastroenterol. 2019 Aug 13;56(2):146-150. doi: 
      10.1590/S0004-2803.201900000-29.