PMID- 31461751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1305-7456 (Print)
IS  - 1305-7464 (Electronic)
VI  - 13
IP  - 3
DP  - 2019 Jul
TI  - Antibacterial and Remineralization Efficacy of Casein Phosphopeptide, 
      Glycomacropeptide Nanocomplex, and Probiotics in Experimental Toothpastes: An In 
      Vitro Comparative Study.
PG  - 391-398
LID - 10.1055/s-0039-1693748 [doi]
AB  - OBJECTIVE:  This article evaluates the antibacterial and remineralization 
      potential of experimentally prepared toothpastes containing different mixtures of 
      nano casein phosphopeptides (nCPP), nano amorphous calcium phosphate (nACP), 
      probiotic - Lactobacillus rhamnosus B-445 (L. rhamnosus), and nano 
      glycomacropeptide (nGMP). MATERIALS AND METHODS:  Five experimental toothpaste 
      samples were prepared and grouped, such that group (A0) was the experimental 
      toothpaste base formula. Groups (A1), (A2), (A3), and (A4) were the experimental 
      toothpastes containing: nCPP; nCPP and nACP; nCPP, nACP, and L. rhamnosus, and 
      nCPP, nACP, and nGMP, -respectively. Group (A5) was the commercial group (GC MI 
      Paste Plus). The five groups were screened against Streptococcus mutans (ATCC 
      25175) growth, and investigated for their remineralizing potentials on 
      demineralized bovine enamel using Vickers -microhardness test (Vickers hardness 
      number [VHN]). Scanning electron microscope (SEM) images were obtained for the 
      demineralized and remineralized enamel of the two most effective toothpastes 
      against in vitro bacterial induced enamel demineralization. Statistical analysis 
      was performed using one-way analysis of variance (ANOVA) as well as repeated 
      measures ANOVA followed by Tukey's post hoc test. RESULTS:  Both (A3) and (A4) 
      were significantly higher in mean inhibition zone -diameters than group (A1) and 
      (A2). Group (A4) showed the highest statistical -significance in the mean 
      difference between VHN values of demineralization and 15 days remineralization 
      period. SEM images showed the deposition of nano-sized particles fill the 
      -microrough surface pattern of the etched enamel. CONCLUSION:  All these findings 
      suggest the use of probiotic, nCPP-nACP, and nGMP as a dental anticariogenic and 
      remineralizing active agents.
CI  - Dental Investigation Society.
FAU - Elgamily, Hanaa
AU  - Elgamily H
AD  - Oral and Dental Research Division, Restorative and Dental Materials Department, 
      National Research Centre, Giza, Egypt.
FAU - Safwat, Engie
AU  - Safwat E
AD  - Oral and Dental Research Division, Restorative and Dental Materials Department, 
      National Research Centre, Giza, Egypt.
FAU - Soliman, Zainab
AU  - Soliman Z
AD  - Operative Dentistry Department, Faculty of Dentistry, Ain Shams University, 
      Cairo, Egypt.
FAU - Salama, Heba
AU  - Salama H
AD  - Division of Food Industries and Nutrition, Food Industries and Nutrition 
      Division, Dairy Science Department, National Research Centre, Giza, Egypt.
FAU - El-Sayed, Hoda
AU  - El-Sayed H
AD  - Division of Food Industries and Nutrition, Food Industries and Nutrition 
      Division, Dairy Science Department, National Research Centre, Giza, Egypt.
FAU - Anwar, Mohamed
AU  - Anwar M
AD  - Operative Dentistry Department, Faculty of Dentistry, Ain Shams University, 
      Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190828
PL  - Germany
TA  - Eur J Dent
JT  - European journal of dentistry
JID - 101303672
PMC - PMC6890513
COIS- Dr. Salama reports a patent under registration no 2017/855 pending. Dr. Safwat 
      reports a patent under registration no 2017/855 pending. Dr. Elgamily reports a 
      patent under registration no 2017/855 pending. Dr. Samir reports a patent under 
      registration no 2017/855 pending.
EDAT- 2019/08/29 06:00
MHDA- 2019/08/29 06:01
PMCR- 2019/08/28
CRDT- 2019/08/29 06:00
PHST- 2019/08/29 06:00 [pubmed]
PHST- 2019/08/29 06:01 [medline]
PHST- 2019/08/29 06:00 [entrez]
PHST- 2019/08/28 00:00 [pmc-release]
AID - EJD1900085 [pii]
AID - 10.1055/s-0039-1693748 [doi]
PST - ppublish
SO  - Eur J Dent. 2019 Jul;13(3):391-398. doi: 10.1055/s-0039-1693748. Epub 2019 Aug 
      28.